List of works - Andres Metspalu

Distribution and medical impact of loss-of-function variants in the Finnish founder population

scientific article

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

scientific article

Genetic structure of Europeans: a view from the North-East

scientific article

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

scientific article

The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies

scientific article

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The transcriptional landscape of age in human peripheral blood

scientific article

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

scientific journal article

Genome-wide association study identifies 30 loci associated with bipolar disorder.

scientific article

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

scientific article

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

scientific article published on 23 March 2016

Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci

scientific journal article

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scientific journal article

Genome-wide association and functional follow-up reveals new loci for kidney function

scientific article

Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays.

scientific article

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

scientific article

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons

scientific article

A recent bottleneck of Y chromosome diversity coincides with a global change in culture

scientific article

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Association analyses based on false discovery rate implicate new loci for coronary artery disease

scientific article published on 17 July 2017

Meta-analysis of microRNA expression in lung cancer

scientific article published on 27 December 2012

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

article

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

scientific article

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

scientific article published in November 2015

RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans

retracted scholarly article

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

scientific article published on 24 April 2017

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

scientific article

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium

scientific article

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genomic analyses inform on migration events during the peopling of Eurasia

scientific article (publication date: 13 October 2016)

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.

scientific article

Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu

scientific article

Genetically determined height and coronary artery disease

scientific article

A 5S rRNA/L5 complex is a precursor to ribosome assembly in mammalian cells

scientific article

Identification of miR-374a as a prognostic marker for survival in patients with early-stage nonsmall cell lung cancer

scientific article

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

scientific article

Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways

scientific article

52 Genetic Loci Influencing Myocardial Mass

scientific article

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

scientific article published on 14 January 2019

Linkage disequilibrium patterns and tagSNP transferability among European populations

scientific article

Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies

scientific article

List of works by Andres Metspalu

Distribution and medical impact of loss-of-function variants in the Finnish founder population

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

Genetic structure of Europeans: a view from the North-East

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

The transcriptional landscape of age in human peripheral blood

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Genome-wide association study identifies 30 loci associated with bipolar disorder.

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

The impact of low-frequency and rare variants on lipid levels

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Genome-wide association and functional follow-up reveals new loci for kidney function

Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays.

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons

A recent bottleneck of Y chromosome diversity coincides with a global change in culture

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Exome-wide association study of plasma lipids in >300,000 individuals

Association analyses based on false discovery rate implicate new loci for coronary artery disease

Meta-analysis of microRNA expression in lung cancer

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Genomic analyses inform on migration events during the peopling of Eurasia

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.

Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu

Genetically determined height and coronary artery disease

A 5S rRNA/L5 complex is a precursor to ribosome assembly in mammalian cells

Identification of miR-374a as a prognostic marker for survival in patients with early-stage nonsmall cell lung cancer

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways

52 Genetic Loci Influencing Myocardial Mass

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Linkage disequilibrium patterns and tagSNP transferability among European populations

Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies