List of works - John A. Porco

Discovery of chemical reactions through multidimensional screening

scientific article published in February 2007

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

scientific article

Remodelling of the natural product fumagillol employing a reaction discovery approach

scientific article published on December 1, 2011

Biomimetic Photocycloaddition of 3‐Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation

scientific article published on September 3, 2010

Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1.

scientific article published in November 2006

Total Synthesis of the Quinone Epoxide Dimer (+)-Torreyanic Acid: Application of a Biomimetic Oxidation/Electrocyclization/Diels−Alder Dimerization Cascade1

scientific article published on April 30, 2003

Discovery of new antimalarial chemotypes through chemical methodology and library development

scientific article published on 15 April 2011

Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4 + 2] dimerization cascade

scientific article

Total synthesis and structure assignment of (+)-hexacyclinol.

scientific article

Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801.

scientific article

Total Synthesis and Absolute Stereochemical Assignment of Kibdelone C

scientific article published on June 15, 2011

Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes

scientific article published in July 2005

Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition

scientific article published in June 2007

Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase.

scientific article published on July 2003

Lobatamide C: total synthesis, stereochemical assignment, preparation of simplified analogues, and V-ATPase inhibition studies

scientific article

Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

scientific article

Silver nanoparticle-catalyzed Diels-Alder cycloadditions of 2'-hydroxychalcones.

scientific article published on June 2010

Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters

scientific article

Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations

scientific article

Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation

scientific article

Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C(1).

scientific article

Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor

scientific article

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

scientific article published on September 14, 2015

A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization

scientific article

Total syntheses of secalonic acids A and D.

scientific article

Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams

scientific article

Total synthesis of the salicylate enamide macrolide oximidine III: application of relay ring-closing metathesis

scientific article published in July 2004

Synthesis of the Azaphilones (+)-Sclerotiorin and (+)-8-O-Methylsclerotiorinamine Utilizing (+)-Sparteine Surrogates in Copper-Mediated Oxidative Dearomatization

scientific article published on March 14, 2011

Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones

scientific article published on February 18, 2011

Total Synthesis of Plukenetione A

scientific article published on October 13, 2010

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.

scientific article

Biomimetic dehydrogenative Diels-Alder cycloadditions: total syntheses of brosimones A and B.

scientific article

The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line

scientific article

Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides

scientific article

Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer

scientific article

Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB.

scientific article published in September 2002

Vinylogous addition of siloxyfurans to benzopyryliums: a concise approach to the tetrahydroxanthone natural products

scientific article

Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin

scientific article

Exploring skeletal diversity via ring contraction of glycal-derived scaffolds

scientific article published in October 2006

Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes

scientific article published on April 16, 2014

Synthesis of epoxyquinol A and related molecules: probing chemical reactivity of epoxyquinol dimers and 2H-pyran precursors

scientific article published in July 2005

Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones

scientific article

Convergent synthesis of a complex oxime library using chemical domain shuffling

scientific article published in June 2005

Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction

scientific article published on January 10, 2014

Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes

scientific article published on 15 March 2007

Total synthesis and stereochemical assignment of the spiroisoxazoline natural product (+)-calafianin

scientific article published on 01 March 2006

Asymmetric Total Synthesis of the Epoxykinamycin FL‐120 B′

scientific article published on August 30, 2011

Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers

scientific article

Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions

scientific article

Enantioselective Total Synthesis and Biological Evaluation of (+)-Kibdelone A and a Tetrahydroxanthone Analogue

scientific article published on July 23, 2013

List of works by John A. Porco

Discovery of chemical reactions through multidimensional screening

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

Remodelling of the natural product fumagillol employing a reaction discovery approach

Biomimetic Photocycloaddition of 3‐Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation

Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1.

Total Synthesis of the Quinone Epoxide Dimer (+)-Torreyanic Acid: Application of a Biomimetic Oxidation/Electrocyclization/Diels−Alder Dimerization Cascade1

Discovery of new antimalarial chemotypes through chemical methodology and library development

Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4 + 2] dimerization cascade

Total synthesis and structure assignment of (+)-hexacyclinol.

Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801.

Total Synthesis and Absolute Stereochemical Assignment of Kibdelone C

Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes

Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition

Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase.

Lobatamide C: total synthesis, stereochemical assignment, preparation of simplified analogues, and V-ATPase inhibition studies

Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

Silver nanoparticle-catalyzed Diels-Alder cycloadditions of 2'-hydroxychalcones.

Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters

Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations

Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation

Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C(1).

Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization

Total syntheses of secalonic acids A and D.

Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams

Total synthesis of the salicylate enamide macrolide oximidine III: application of relay ring-closing metathesis

Synthesis of the Azaphilones (+)-Sclerotiorin and (+)-8-O-Methylsclerotiorinamine Utilizing (+)-Sparteine Surrogates in Copper-Mediated Oxidative Dearomatization

Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones

Total Synthesis of Plukenetione A

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.

Biomimetic dehydrogenative Diels-Alder cycloadditions: total syntheses of brosimones A and B.

The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line

Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides

Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer

Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB.

Vinylogous addition of siloxyfurans to benzopyryliums: a concise approach to the tetrahydroxanthone natural products

Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin

Exploring skeletal diversity via ring contraction of glycal-derived scaffolds

Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes

Synthesis of epoxyquinol A and related molecules: probing chemical reactivity of epoxyquinol dimers and 2H-pyran precursors

Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones

Convergent synthesis of a complex oxime library using chemical domain shuffling

Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction

Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes

Total synthesis and stereochemical assignment of the spiroisoxazoline natural product (+)-calafianin

Asymmetric Total Synthesis of the Epoxykinamycin FL‐120 B′

Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers

Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions

Enantioselective Total Synthesis and Biological Evaluation of (+)-Kibdelone A and a Tetrahydroxanthone Analogue