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List of works by John D Isaacs

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Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

scientific article
Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

scientific article
Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells

scientific article published on 01 August 2007
Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

scientific article published on 29 January 2013
Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions

scientific article
Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study.

scientific article
Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis

article
Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis

scientific article published on 28 March 2008
Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis

scientific article published in February 1996
Elucidation of the relationship between synovitis and bone damage: A randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis

article
Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis.

scientific article published on 15 June 2010
Humanised monoclonal antibody therapy for rheumatoid arthritis

scientific article published in The Lancet
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.

scientific article
Cytokines in rheumatoid arthritis - shaping the immunological landscape

scientific article
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis

scientific article
Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells

scientific article
Integrated safety in tocilizumab clinical trials

scientific article published in September 2011
Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis

scientific article published on 26 April 2016
Development of dendritic cell-based immunotherapy for autoimmunity

scientific article published on April 2010
The role of biosimilars in the treatment of rheumatic diseases

scientific article published on 19 December 2012
Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci

scientific article
Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: a meta-analysis

scientific article
Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

scientific article published on 17 May 2013
Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells

scientific article published on 22 April 2008
Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.

scientific article
Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis

scientific article published on 8 August 2002
Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses

article
Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?

scientific article
Low-strength T-cell activation promotes Th17 responses.

scientific article
Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy

scientific article published in The Lancet
Biologic therapies in rheumatology: lessons learned, future directions

scientific article published on January 2007
Prospective study of anti-tumour necrosis factor receptor superfamily 1B fusion protein, and case study of anti-tumour necrosis factor receptor superfamily 1A fusion protein, in tumour necrosis factor receptor associated periodic syndrome (TRAPS): c

scientific article published on February 2003
LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells.

scientific article published on 6 November 2008
Anti-TNF therapy

scientific article published on August 2011
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response

scientific article published on April 2015
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy

scientific article published on July 2010
Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?

scientific article published in August 2017
Fcgamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups

scientific article published on 01 October 2000
Pathophysiology of rheumatoid arthritis

scientific article published on May 2011
Synovial CD4+ T-cell-derived GM-CSF supports the differentiation of an inflammatory dendritic cell population in rheumatoid arthritis.

scientific article
A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation

scientific article published on July 2005
Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort

scientific article
Synovial tissue research: a state-of-the-art review

scientific article
The need for personalised medicine for rheumatoid arthritis

scientific article published on 10 November 2010
A randomised, controlled, double blinded study of ultrasound guided corticosteroid joint injection in patients with inflammatory arthritis

scientific article published on 01 July 2010
Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up

scientific article
Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis

article
A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.

scientific article
Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

scientific article
Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF B signalling pathways

article

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