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List of works by John D Isaacs

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Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis

scientific article
Treg cells in rheumatoid arthritis: an update

scientific article published on September 2013
Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23

scientific article (publication date: November 2016)
Efficacy of a single ultrasound-guided injection for the treatment of hip osteoarthritis

scientific article published on 10 November 2010
The changing face of rheumatoid arthritis: sustained remission for all?

scientific article
Treatment of stiff person syndrome with rituximab.

scientific article
CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study

scientific article published on 22 December 2015
Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis

scientific article published on May 2015
Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients

scientific article
IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis

scientific article published on 3 February 2015
Regulatory T cells and autoimmunity

scientific article published on July 2009
Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future.

scientific article published on 25 May 2008
Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis

scientific article published on January 2013
Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis

scientific article published on 27 January 2016
Neutralizing tumor necrosis factor activity leads to remission in patients with refractory noninfectious posterior uveitis

scientific article published in June 2004
Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B.

scientific article
Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis

scientific article published on 28 February 2012
Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis

scientific article published on 22 September 2009
Determination of thymic function directly from peripheral blood: a validated modification to an established method.

scientific article published on 12 October 2008
Current concepts in the pathogenesis of early rheumatoid arthritis

scientific article published on February 2009
FcγRIIIa expression on monocytes in rheumatoid arthritis: role in immune-complex stimulated TNF production and non-response to methotrexate therapy

scientific article published on 3 January 2012
Monoclonal antibody therapy of chronic intraocular inflammation using Campath-1H.

scientific article published on November 1995
Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment

scientific article
Biosimilars in immune-mediated inflammatory diseases: initial lessons from the first approved biosimilar anti-tumour necrosis factor monoclonal antibody.

scientific article published on 25 September 2015
Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis

scientific article published on January 2006
CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

article
Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

scientific article
Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T cells partly via transforming growth factor-β1.

scientific article published on 26 September 2016
Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice.

scientific article published on January 2006
High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort

scientific article published on 31 May 2016
Therapeutic agents for patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor-alpha antagonists

scientific article published on December 2009
Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: twelve-year outcomes

scientific article published on February 2008
Changes in serum creatinine in patients with active rheumatoid arthritis treated with tofacitinib: results from clinical trials

scientific article
Evaluation of the effect of tofacitinib on measured glomerular filtration rate in patients with active rheumatoid arthritis: results from a randomised controlled trial

scientific article published on 6 April 2015
A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans

scientific article published on 01 December 1996
Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients

scientific article published in April 2009
Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H

scientific article published on 01 January 1995
Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen-induced anergy

scientific article
The impact of glycosylation on HLA-DR1-restricted T cell recognition of type II collagen in a mouse model.

scientific article published in February 2006
Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse.

scientific article published on 20 July 2007
High-dose cyclophosphamide with stem cell rescue for severe rheumatoid arthritis: Short-term efficacy correlates with reduction of macroscopic and histologic synovitis

article
Anti-TNFα Therapy Modulates the Phenotype of Peripheral Blood CD4+T Cells in Patients with Posterior Segment Intraocular Inflammation

scientific article published on 01 January 2004
Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ASK8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study.

scientific article
Atacicept, a novel B cell-targeting biological therapy for the treatment of rheumatoid arthritis.

scientific article published on July 2009
The value of synovial cytokine expression in predicting the clinical response to TNF antagonist therapy (infliximab).

scientific article published on 26 July 2008
Local bioactive tumour necrosis factor (TNF) in corneal allotransplantation

scientific article published on 01 October 2000
Incidence of corneal melting in association with systemic disease in the Yorkshire Region, 1995-7

scientific article
Predicting persistent inflammatory arthritis amongst early arthritis clinic patients in the UK: is musculoskeletal ultrasound required?

scientific article published on January 2013
T cell immunomodulation--the Holy Grail of therapeutic tolerance

scientific article published on 3 July 2007
Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis.

scientific article published on 09 June 2016

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