List of works - John E. Ladbury

A landscape of driver mutations in melanoma

scientific article

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

scientific article

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

scientific article published on 01 December 1994

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

scientific article

Two EGF molecules contribute additively to stabilization of the EGFR dimer

scientific article

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression

scientific article

Adding calorimetric data to decision making in lead discovery: a hot tip

article

Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies

scientific article published on August 15, 1997

Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

scientific article

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

scientific article published on 26 April 2013

The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design

article

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein

scientific article

H-NS forms a superhelical protein scaffold for DNA condensation

scientific article

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

scientific article

Inhibition of basal FGF receptor signaling by dimeric Grb2

scientific article

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

scientific article

H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.

scientific article

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

scientific article

T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes

scientific article published on 25 March 2010

The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

scientific article

Conformational changes in the AAA ATPase p97-p47 adaptor complex

scientific article published on 3 May 2006

Extent of enthalpy-entropy compensation in protein-ligand interactions.

scientific article

Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.

scientific article

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

scientific article

The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon

scientific article published on May 29, 1998

Heat capacity effects of water molecules and ions at a protein-DNA interface

scientific article

Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.

scientific article published on July 2000

Noise in cellular signaling pathways: causes and effects

scientific article published on February 15, 2012

Erythropoietin Stimulates Tumor Growth via EphB4.

scientific article published on 14 October 2015

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

scientific article published on July 2008

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

scientific article published on 16 November 2015

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.

scientific article published on 2 August 2008

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems

scientific article published on 7 June 2012

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans

scientific article published in December 2014

Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid

scientific article published on 18 November 2011

Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat

scientific article

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

scientific article published on August 2010

Survey of the year 2005: literature on applications of isothermal titration calorimetry

scientific article published on January 2007

Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.

scientific article published in February 2006

Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry 1 1Edited by P. E. Wright

article

The extended interface: measuring non-local effects in biomolecular interactions

scientific article published in October 2004

Alternative Modes of Tyrosyl Phosphopeptide Binding to a Src Family SH2 Domain: Implications for Regulation of Tyrosine Kinase Activity†

article

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion

scientific article published on 19 January 2014

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

scientific article published on February 2013

Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).

scientific article published on December 2008

Application of isothermal titration calorimetry in the biological sciences: things are heating up!

scientific article

Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position

scientific article

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

scientific article

A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis

scientific article published on 20 March 2015

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling

scientific article

List of works by John E. Ladbury

A landscape of driver mutations in melanoma

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

Two EGF molecules contribute additively to stabilization of the EGFR dimer

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression

Adding calorimetric data to decision making in lead discovery: a hot tip

Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies

Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein

H-NS forms a superhelical protein scaffold for DNA condensation

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

Inhibition of basal FGF receptor signaling by dimeric Grb2

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes

The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

Conformational changes in the AAA ATPase p97-p47 adaptor complex

Extent of enthalpy-entropy compensation in protein-ligand interactions.

Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon

Heat capacity effects of water molecules and ions at a protein-DNA interface

Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.

Noise in cellular signaling pathways: causes and effects

Erythropoietin Stimulates Tumor Growth via EphB4.

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans

Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid

Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

Survey of the year 2005: literature on applications of isothermal titration calorimetry

Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.

Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry 1 1Edited by P. E. Wright

The extended interface: measuring non-local effects in biomolecular interactions

Alternative Modes of Tyrosyl Phosphopeptide Binding to a Src Family SH2 Domain: Implications for Regulation of Tyrosine Kinase Activity†

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).

Application of isothermal titration calorimetry in the biological sciences: things are heating up!

Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling