List of works - John E. Ladbury

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer

scientific article published on 11 November 2014

Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria

scientific article published on 8 June 2009

A Structural Characterization of the Interactions between Titin Z-Repeats and the α-Actinin C-Terminal Domain

scientific article published on 01 April 2001

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin

scientific article published on 19 April 2015

Counting the calories to stay in the groove.

scientific article published on July 1995

Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48

scientific article published in Journal of Biological Chemistry

Survey of the year 2004: literature on applications of isothermal titration calorimetry

scientific article

Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity

scientific article

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

scientific article

Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX

scientific article

Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator

scientific article (publication date: 5 June 2001)

A survey of the year 2002 literature on applications of isothermal titration calorimetry

scientific article published on November 2003

Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation

scientific article published in June 2007

Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains

scientific article

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli

scientific article

Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry

scientific article

Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering

scientific article

A survey of the year 2003 literature on applications of isothermal titration calorimetry

scientific article published in November 2004

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer

scientific article

Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design

scientific article

Specificity is complex and time consuming: mutual exclusivity in tyrosine kinase-mediated signaling

scientific article

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus

scientific article

Substitution of Charged Residues into the Hydrophobic Core of Escherichia coli Thioredoxin Results in a Change in Heat Capacity of the Native Protein

scientific article published on 01 February 1995

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

scientific article published on 04 March 2016

The hidden thermodynamics of a zinc finger

scientific article

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function

scientific article published on 24 June 2015

Probing cocaine-antibody interactions in buffer and human serum

scientific article

A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein

scientific article

Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity

scientific article (publication date: 2014)

The thermodynamics of formation of a three-strand, DNA three-way junction complex.

scientific article published on June 1994

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

scientific article published on 27 October 2015

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma

scientific article published on 15 September 2015

Inhibitors to the Src SH2 domain: a lesson in structure--thermodynamic correlation in drug design.

scientific article published in June 2001

Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications

scientific article

Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone

article

Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands

scientific article

SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation

scientific article published on 09 August 2013

Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.

scientific article published on 21 July 2009

StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI.

scientific article

Specific DNA Recognition by the Type II Restriction Endonuclease MunI: The Effect of pH

scientific article published on December 11, 2001

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II

scientific article published on 14 January 2016

Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy

scientific article published in May 2002

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors

scientific article published on 3 June 2015

A complex of Shc and Ran-GTPase localises to the cell nucleus

scientific article published on 01 February 2009

Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation

article

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

scientific article published on August 2013

T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation

scientific article published on 27 May 2010

Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex

scientific article published on February 2009

A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly

scientific article published on 18 April 2019

Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors

scientific article

List of works by John E. Ladbury

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer

Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria

A Structural Characterization of the Interactions between Titin Z-Repeats and the α-Actinin C-Terminal Domain

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin

Counting the calories to stay in the groove.

Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48

Survey of the year 2004: literature on applications of isothermal titration calorimetry

Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX

Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator

A survey of the year 2002 literature on applications of isothermal titration calorimetry

Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation

Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli

Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry

Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering

A survey of the year 2003 literature on applications of isothermal titration calorimetry

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer

Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design

Specificity is complex and time consuming: mutual exclusivity in tyrosine kinase-mediated signaling

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus

Substitution of Charged Residues into the Hydrophobic Core of Escherichia coli Thioredoxin Results in a Change in Heat Capacity of the Native Protein

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

The hidden thermodynamics of a zinc finger

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function

Probing cocaine-antibody interactions in buffer and human serum

A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein

Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity

The thermodynamics of formation of a three-strand, DNA three-way junction complex.

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma

Inhibitors to the Src SH2 domain: a lesson in structure--thermodynamic correlation in drug design.

Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications

Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone

Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands

SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation

Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.

StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI.

Specific DNA Recognition by the Type II Restriction Endonuclease MunI: The Effect of pH

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II

Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors

A complex of Shc and Ran-GTPase localises to the cell nucleus

Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation

Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex

A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly

Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors