List of works - Gerald I. Shulman

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

scientific article (publication date: June 2001)

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

scientific journal article

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

scientific article (publication date: 16 May 2003)

Disruption of IRS-2 causes type 2 diabetes in mice

scientific article

Mitochondrial dysfunction and type 2 diabetes

scientific article (publication date: 21 January 2005)

Mechanisms for insulin resistance: common threads and missing links

scientific article (publication date: 2 March 2012)

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

scientific article

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

scientific article published on 27 May 2004

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

scientific article

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

scientific article (publication date: October 2004)

Mechanism of free fatty acid-induced insulin resistance in humans

scientific article

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

scientific article published in January 1999

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

scientific article (publication date: 8 February 2001)

Lipid-induced insulin resistance: unravelling the mechanism

scientific article

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

scientific article

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

scientific article

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

scientific article published in August 2000

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

scientific article published on 01 July 2000

Disordered lipid metabolism and the pathogenesis of insulin resistance

scientific article

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

scientific article published on June 2001

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

scientific article

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

scientific article

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

scientific article published on January 2014

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

scientific article published on 01 June 1999

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

scientific article

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

scientific article

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

scientific article published on 30 July 2008

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

scientific article

Prevention of fat-induced insulin resistance by salicylate

scientific article

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

scientific article

A guide to analysis of mouse energy metabolism

scientific article published on 28 December 2011

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

scientific article published on June 2014

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

scientific article published on March 26, 1998

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

scholarly article

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

scientific article published on 16 August 2010

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

scientific article published on 5 June 2001

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

scientific article

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

scientific article (publication date: May 2002)

Etiology of insulin resistance

scientific article

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

scientific journal article

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

scientific article published on 4 January 2016

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

scientific article published on 8 February 2004

PKC-theta knockout mice are protected from fat-induced insulin resistance

scientific article

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

scientific article

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis

scientific article

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

scientific article

Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease

scientific article published on September 2014

Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

scientific article

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

scientific journal article

Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects

scientific article published on 01 October 1996

List of works by Gerald I. Shulman

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Disruption of IRS-2 causes type 2 diabetes in mice

Mitochondrial dysfunction and type 2 diabetes

Mechanisms for insulin resistance: common threads and missing links

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

Mechanism of free fatty acid-induced insulin resistance in humans

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Lipid-induced insulin resistance: unravelling the mechanism

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

Disordered lipid metabolism and the pathogenesis of insulin resistance

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

Prevention of fat-induced insulin resistance by salicylate

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

A guide to analysis of mouse energy metabolism

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

Etiology of insulin resistance

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

PKC-theta knockout mice are protected from fat-induced insulin resistance

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease

Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects