List of works - Gerald I. Shulman

Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

scientific article

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

scientific article published in February 2007

Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients

scientific article

Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity

scientific article published in April 2002

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

scientific article published on 31 December 2006

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk

scientific article

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

scientific journal article

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia

scientific article published in May 2007

Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning

scientific article

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

scientific article published on 5 February 2015

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

scientific article published on 16 February 2006

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

scientific article

Diacylglycerol-mediated insulin resistance

scientific article

Regulation of mitochondrial biogenesis

scientific article

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes

scientific article published on February 2014

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

scientific article

Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease

scientific article

Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

scientific article

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

scientific journal article

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

scientific article

The role of AMP-activated protein kinase in mitochondrial biogenesis

scientific article

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

scholarly article

Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men.

scholarly article

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

scientific journal article

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents

scientific article

STAT3 inhibition of gluconeogenesis is downregulated by SirT1

scientific article published on 22 March 2009

Skeletal muscle lipid metabolism with obesity

scientific article published on 27 December 2002

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

scientific journal article

Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

scientific article

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

scientific article published on 01 March 2000

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

scientific article

Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism

scientific article

Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

scientific article

Development of insulin resistance in mice lacking PGC-1α in adipose tissues.

scientific article

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

scholarly article

Type 2 diabetes mellitus

article

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

scientific article

Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release

scientific article published on 01 February 1995

Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

scientific article published on October 1987

The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

scientific article

Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

scientific article published on April 1994

SirT1 regulates adipose tissue inflammation

scientific article published on December 2011

A cluster of metabolic defects caused by mutation in a mitochondrial tRNA.

scientific article

Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance

scientific article

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity

scientific article

Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study.

scientific article published in June 1997

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats

scientific article published in October 2002

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes

scientific article published in August 2007

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy

scientific article

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

scientific article published in December 2000

List of works by Gerald I. Shulman

Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients

Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia

Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Diacylglycerol-mediated insulin resistance

Regulation of mitochondrial biogenesis

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease

Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

The role of AMP-activated protein kinase in mitochondrial biogenesis

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men.

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents

STAT3 inhibition of gluconeogenesis is downregulated by SirT1

Skeletal muscle lipid metabolism with obesity

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism

Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

Development of insulin resistance in mice lacking PGC-1α in adipose tissues.

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Type 2 diabetes mellitus

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release

Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

SirT1 regulates adipose tissue inflammation

A cluster of metabolic defects caused by mutation in a mitochondrial tRNA.

Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity

Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study.

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.