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List of works by Matthias Dobbelstein

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

scientific article published in January 1998
p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest

scientific article
Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

scientific article published on May 2005
Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence

scientific article published on July 16, 1997
A polymorphic microsatellite that mediates induction of PIG3 by p53.

scientific article
p21/CDKN1A mediates negative regulation of transcription by p53.

scientific article published on 13 May 2003
Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

scientific article published on 25 May 2015
E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

scientific article
Exploiting replicative stress to treat cancer

scientific article published on 08 May 2015
The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

scientific article
p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop

scientific article published on July 2002
Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

scientific article published on 01 March 1999
Targeting tumour-supportive cellular machineries in anticancer drug development

scientific article published on March 2014
p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis

scientific article published on December 2010
MicroRNA-449 in cell fate determination

scientific article published on September 1, 2011
Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product

scientific article published in September 1996
Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy

scientific article published on November 2006
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

scientific article published on 23 January 2012
In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries

scientific article published in December 1995
Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.

scientific article published on 7 August 2013
Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes

scientific article published on February 7, 2011
E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53.

scientific article
Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.

scientific article
YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter

scientific article published on 11 January 2002
Adenovirus type 5 E4orf3 protein relieves p53 inhibition by E1B-55-kilodalton protein.

scientific article published on March 1999
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart

scientific article (publication date: 16 September 2011)
The nuclear export signal within the E4orf6 protein of adenovirus type 5 supports virus replication and cytoplasmic accumulation of viral mRNA.

scientific article published on January 2000
The large T antigen of simian virus 40 binds and inactivates p53 but not p73.

scientific article published in December 1998
E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection

scientific article published on July 2004
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

scientific article published on 30 September 2013
MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

scientific article
Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice

scientific article
Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells

scientific article published on May 1992
MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP.

scientific article
MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia

scientific article published on 15 November 2010
HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

scientific article
NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue

scientific article
The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins

scientific article published on 20 March 2009
Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny

scientific article published on February 2006
Differential regulation of p63 and p73 expression

scientific article published on 01 August 2003
TAp73 is essential for germ cell adhesion and maturation in testis.

scientific article published on 24 March 2014
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways

scientific article published on July 2008
p73 and p63: why do we still need them?

scientific journal article
Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression

scientific article published on 27 May 2009
Export of hepatitis B virus RNA on a Rev-like pathway: inhibition by the regenerating liver inhibitory factor IkappaB alpha.

scientific article published in November 1997
Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain

scientific article published on 01 March 2000
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma

scientific article published on 01 September 2006
DeltaNp73 can modulate the expression of various genes in a p53-independent fashion

scientific article
While p73 is essential, p63 is completely dispensable for the development of the central nervous system

scientific article
Failure of viral oncoproteins to target the p53-homologue p51A

scientific article published on 01 December 1999

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