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List of works by Alexander J. Lazar

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Genomic Classification of Cutaneous Melanoma

scientific article
Oncogenic Signaling Pathways in The Cancer Genome Atlas

scientific article published in April 2018
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.

scientific article published on 2 November 2017
The Immune Landscape of Cancer

scientific article published on 4 April 2018
Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.

scientific article published on 8 December 2015
NRAS mutation status is an independent prognostic factor in metastatic melanoma

scientific article
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

scientific article published in April 2018
Comprehensive Characterization of Cancer Driver Genes and Mutations

scientific article published in April 2018
Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

scientific article published in April 2018
Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

scientific article published on 14 June 2016
Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual

scientific article published on 13 October 2017
Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma

scientific article
Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors.

scientific article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial

scientific article published on 4 October 2017
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.

scientific article
Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials

scientific article
A novel AKT3 mutation in melanoma tumours and cell lines

scientific article published on 23 September 2008
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

scientific article published on August 2017
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

scientific article published in April 2018
Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma

scientific article
Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review.

scientific article published on 5 March 2018
Recurrent PTPRB and PLCG1 mutations in angiosarcoma

scientific article
Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects

scientific article (publication date: 13 October 1998)
Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma

scientific article published on December 2009
Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST).

scientific article
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

scientific article published on 11 May 2012
Optimizing Treatment of Desmoid Tumors

article
Clinical, Pathological, and Molecular Variables Predictive of Malignant Peripheral Nerve Sheath Tumor Outcome

article
Retracted: Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies

retracted article
Genomic and Functional Approaches to Understanding Cancer Aneuploidy

scientific article published on 31 March 2018
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

scientific article published on 30 March 2007
Pathogenic Germline Variants in 10,389 Adult Cancers

scientific article published in April 2018
Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates

scientific article
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

scientific article published on 8 October 2018
Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF(V600E) mutation

scientific article published on 17 July 2013
Genetic alterations in signaling pathways in melanoma

scientific article
Vimentin is a novel AKT1 target mediating motility and invasion

scientific article
Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor

scientific article
Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK.

scientific article published in January 2011
Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma

scientific article
Modeling Ewing sarcoma tumors in vitro with 3D scaffolds

scientific article published on April 2013
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

scientific article published in April 2018
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

scientific article published in April 2018
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

scientific article
A randomized, phase II study of preoperative plus postoperative imatinib in GIST: evidence of rapid radiographic response and temporal induction of tumor cell apoptosis

scientific article
CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors

scientific article published on 21 February 2013
Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

scientific article published on 12 November 2018
Angiosarcoma: clinical and molecular insights

scientific article published in June 2010
Ewing's sarcoma: standard and experimental treatment options

scientific article published on April 2009

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