List of works - Frank Maldarelli

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

scholarly article

Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

scientific article published on 08 December 2008

Towards an HIV cure: a global scientific strategy

scientific article

New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma

scientific article published on October 2003

Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis

scientific article

ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia

scientific article

Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection

scientific article

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

scientific article published on 8 February 2016

Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy

scientific article

Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule

scientific article

Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function

scientific article published on 13 March 2003

High Dose Atorvastatin Decreases Cellular Markers of Immune Activation Without Affecting HIV-1 RNA Levels: Results of a Double-blind Randomized Placebo Controlled Clinical Trial

scientific article published on February 15, 2011

Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance

scholarly article

HIV-1 continues to replicate and evolve in patients with natural control of HIV infection

scientific article

Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision

scientific article

Analysis of 454 sequencing error rate, error sources, and artifact recombination for detection of Low-frequency drug resistance mutations in HIV-1 DNA.

scientific article published on 13 February 2013

Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection

scientific article

Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase

scientific article

XMRV: A New Virus in Prostate Cancer?

scientific article published on October 21, 2010

Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways

scholarly article

Single cell analysis of lymph node tissue from HIV-1 infected patients reveals that the majority of CD4+ T-cells contain one HIV-1 DNA molecule

scientific article

Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor

scientific article

Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy

scientific article

Therapeutic vaccination expands and improves the function of the HIV-specific memory T-cell repertoire

scientific article published on 12 March 2013

Clinical Management of HIV Drug Resistance

scientific article published on April 14, 2011

HIV-1 Infection Leads to Increased Transcription of Human Endogenous Retrovirus HERV-K (HML-2) ProvirusesIn Vivobut Not to Increased Virion Production

scientific article published on July 23, 2014

Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy

scientific article

Transmitted raltegravir resistance in an HIV-1 CRF_AG-infected patient

scientific article

Evaluation of sequence ambiguities of the HIV-1 pol gene as a method to identify recent HIV-1 infection in transmitted drug resistance surveys

scientific article

Activation of HIV-1 from Latent Infection via Synergy of RUNX1 Inhibitor Ro5-3335 and SAHA

scientific article (publication date: March 2014)

Patterns of Human Immunodeficiency Virus type 1 recombination ex vivo provide evidence for coadaptation of distant sites, resulting in purifying selection for intersubtype recombinants during replication.

scientific article

Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy: final 48-week clinical and virologic outcomes

scientific article published on March 2009

Ongoing HIV Replication During ART Reconsidered

article

A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection

scientific article

Multiple sources of contamination in samples from patients reported to have XMRV infection

scientific article (publication date: 2012)

Pomalidomide for Symptomatic Kaposi's Sarcoma in People With and Without HIV Infection: A Phase I/II Study

scientific article

Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA.

scientific article

Transmitted HIV Drug Resistance Is High and Longstanding in Metropolitan Washington, DC

scientific article

Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir

scientific article

Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with a simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptase

scientific article

Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1

scientific article

Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy

scientific article published on June 2009

Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization

scientific article

The role of HIV integration in viral persistence: no more whistling past the proviral graveyard

scientific article published on February 1, 2016

RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy

scientific article

Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency

scientific article published on 12 December 2018

Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: a randomized controlled trial

scientific article

Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance

scientific article published on 13 October 2012

Genotypic Resistance at Viral Rebound Among Patients Who Received Lopinavir/Ritonavir-Based or Efavirenz-Based First Antiretroviral Therapy in South Africa

scientific article published on November 1, 2011

No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication

scientific article published on 25 September 2019

List of works by Frank Maldarelli

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

Towards an HIV cure: a global scientific strategy

New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma

Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis

ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia

Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy

Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule

Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function

High Dose Atorvastatin Decreases Cellular Markers of Immune Activation Without Affecting HIV-1 RNA Levels: Results of a Double-blind Randomized Placebo Controlled Clinical Trial

Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance

HIV-1 continues to replicate and evolve in patients with natural control of HIV infection

Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision

Analysis of 454 sequencing error rate, error sources, and artifact recombination for detection of Low-frequency drug resistance mutations in HIV-1 DNA.

Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection

Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase

XMRV: A New Virus in Prostate Cancer?

Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways

Single cell analysis of lymph node tissue from HIV-1 infected patients reveals that the majority of CD4+ T-cells contain one HIV-1 DNA molecule

Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor

Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy

Therapeutic vaccination expands and improves the function of the HIV-specific memory T-cell repertoire

Clinical Management of HIV Drug Resistance

HIV-1 Infection Leads to Increased Transcription of Human Endogenous Retrovirus HERV-K (HML-2) ProvirusesIn Vivobut Not to Increased Virion Production

Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy

Transmitted raltegravir resistance in an HIV-1 CRF_AG-infected patient

Evaluation of sequence ambiguities of the HIV-1 pol gene as a method to identify recent HIV-1 infection in transmitted drug resistance surveys

Activation of HIV-1 from Latent Infection via Synergy of RUNX1 Inhibitor Ro5-3335 and SAHA

Patterns of Human Immunodeficiency Virus type 1 recombination ex vivo provide evidence for coadaptation of distant sites, resulting in purifying selection for intersubtype recombinants during replication.

Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy: final 48-week clinical and virologic outcomes

Ongoing HIV Replication During ART Reconsidered

A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection

Multiple sources of contamination in samples from patients reported to have XMRV infection

Pomalidomide for Symptomatic Kaposi's Sarcoma in People With and Without HIV Infection: A Phase I/II Study

Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA.

Transmitted HIV Drug Resistance Is High and Longstanding in Metropolitan Washington, DC

Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir

Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with a simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptase

Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1

Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy

Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization

The role of HIV integration in viral persistence: no more whistling past the proviral graveyard

RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy

Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency

Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: a randomized controlled trial

Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance

Genotypic Resistance at Viral Rebound Among Patients Who Received Lopinavir/Ritonavir-Based or Efavirenz-Based First Antiretroviral Therapy in South Africa

No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication