List of works - David J Kwiatkowski

Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs

scientific article

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

scientific article

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

scientific article

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

scientific article (publication date: March 2002)

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular

scientific article

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

scientific article

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

scientific article published on October 1, 2003

The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

scientific article (publication date: 8 September 2014)

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

scientific article

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

scientific article published on May 2008

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

scientific article published on July 12, 2012

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

scientific article published on 23 May 2011

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

scientific journal article

Rapid turnover of actin in dendritic spines and its regulation by activity.

scientific article published in March 2002

Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases

scientific article published on October 17, 2003

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

scientific journal article

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

scientific article

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

scientific article (publication date: 6 July 2011)

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

scientific journal article

Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

scientific article published on September 1, 2003

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

scientific article published on 2 March 2016

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

scientific article published on 8 February 2007

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures

scientific article published in September 2002

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors

scientific article

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors

article

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

scientific article published on June 2003

Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis

scientific journal article

Somatic LKB1 mutations promote cervical cancer progression

scientific article

Response and acquired resistance to everolimus in anaplastic thyroid cancer

scientific article

mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation

scientific article

Tuberous sclerosis complex proteins control axon formation

scientific journal article

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.

scientific article

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

scientific journal article

Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors

scientific article published on 4 January 2010

Coordinated regulation of protein synthesis and degradation by mTORC1

scientific article (publication date: 18 September 2014)

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

scientific article

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

scientific article

Requirement of Rac1 in the development of cardiac hypertrophy.

scholarly article

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

scholarly article

Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience

scientific article published on May 2015

Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models

scientific article published in March 2005

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

scientific article published on July 11, 2011

The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).

scientific article published on 2 June 2004

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors

scientific article published on 25 April 2016

Institutional implementation of clinical tumor profiling on an unselected cancer population

scientific article published on 17 November 2016

Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.

scientific article published in December 2004

Perivascular epithelioid cell neoplasms: pathology and pathogenesis

scientific article

Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case–control disease association studies

article

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner

scientific article published on May 2009

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

scientific article published on April 19, 2003

List of works by David J Kwiatkowski

Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

Rapid turnover of actin in dendritic spines and its regulation by activity.

Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis

Somatic LKB1 mutations promote cervical cancer progression

Response and acquired resistance to everolimus in anaplastic thyroid cancer

mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation

Tuberous sclerosis complex proteins control axon formation

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors

Coordinated regulation of protein synthesis and degradation by mTORC1

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

Requirement of Rac1 in the development of cardiac hypertrophy.

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience

Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors

Institutional implementation of clinical tumor profiling on an unselected cancer population

Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.

Perivascular epithelioid cell neoplasms: pathology and pathogenesis

Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case–control disease association studies

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma