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Authors whose works are in public domain in at least one jurisdiction

List of works by Jerry W Shay

1-50 of 284 results

Extension of life-span by introduction of telomerase into normal human cells

scientific article

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

scientific article published on December 23, 1994

A transcriptionally active DNA-binding site for human p53 protein complexes

scientific article published on June 1992

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

scientific article

Human telomerase and its regulation

scientific article

Senescence and immortalization: role of telomeres and telomerase

scientific article published on 7 October 2004

A role for both RB and p53 in the regulation of human cellular senescence

scientific article published on 01 September 1991

Functional requirement of p23 and Hsp90 in telomerase complexes

scientific journal article

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

scientific article published on December 1999

Correlating telomerase activity levels with human neuroblastoma outcomes

scientific article published on 01 March 1995

Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

scientific article published on September 1995

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

scientific article

Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling

scientific article

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

scientific article published on July 1989

Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer

scientific article published on December 1998

Role of telomeres and telomerase in cancer

scientific article

Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.

scientific article published in February 2006

Regulation of telomerase activity in immortal cell lines

scientific article published on June 1996

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination

scientific article published on June 1, 2011

Telomerase Activity in Small-Cell and Non-Small-Cell Lung Cancers

scientific article published on June 21, 1995

Historical claims and current interpretations of replicative aging

scientific article

Telomerase therapeutics for cancer: challenges and new directions

scientific article published on 9 June 2006

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

scientific article published on 23 June 2005

Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies

scientific article published on 8 June 2007

Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells

scientific article published on August 2009

Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again

scientific article

Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line

scientific article published on February 2005

A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies

scientific article

Telomerase activity in human breast tumors

scientific article published on 01 January 1996

Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

scientific article

Telomerase: a target for cancer therapeutics

scientific article

Does a sentinel or a subset of short telomeres determine replicative senescence?

scientific article published on 04 June 2004

Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells

scientific article published on December 1, 2001

Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers

scientific article published on May 2007

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.

scientific article

BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

scientific article

The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth

scientific article

Telomeres and telomerase in normal and cancer stem cells

scientific article

Telomere positional effects and the regulation of cellular senescence

scientific article published on 01 June 1992

Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition

scientific article published on May 2004

An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity

scientific article

Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer

scientific article published on June 2004

Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation

scientific article

Telomere-end processing the terminal nucleotides of human chromosomes

scientific article published on 01 April 2005

In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor

scientific article published on September 2005

Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro

scientific article

hTERT associates with human telomeres and enhances genomic stability and DNA repair

scientific article published on 01 January 2003

Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations

scientific article published on 28 February 2013

Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro

scientific article

Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels

scientific article published on June 1999