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List of works by Pradipsinh K. Rathod

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Chemical genetics of Plasmodium falciparum

scientific article (publication date: 20 May 2010)
A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes

scientific article
Variations in frequencies of drug resistance in Plasmodium falciparum

scientific article published on August 19, 1997
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

scientific article
A membrane network for nutrient import in red cells infected with the malaria parasite

scientific article published in May 1997
Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria

scientific article
Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

scientific article published on May 1, 1982
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article
Plasmodium Dihydroorotate Dehydrogenase: A Promising Target for Novel Anti-Malarial Chemotherapy

scientific article published on June 1, 2010
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

scientific article published on 04 June 2008
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

scientific article
Divergent regulation of dihydrofolate reductase between malaria parasite and human host

scientific article
Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network

scientific article published on August 10, 2015
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

scientific article published on April 2009
A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates

scientific article
Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development

scientific article published on 16 May 2008
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

scientific article
Regulatory hotspots in the malaria parasite genome dictate transcriptional variation

scientific article
Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

scientific article
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum

scientific article published on 20 January 2005
Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

scientific article
Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum

scientific article published on April 1, 1992
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

scientific article published on 19 August 2002
Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass.

scientific article published on 16 May 2016
Deformability limits of Plasmodium falciparum-infected red blood cells

scientific article published on 30 April 2009
Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach

scientific article published on August 10, 2015
Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications

scientific article
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum

scientific article
DNA microarrays for malaria

scientific article published in January 2002
Microfluidic modeling of cell-cell interactions in malaria pathogenesis

scientific article (publication date: July 2007)
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro

scientific article
Malaria in South Asia: prevalence and control

scientific article
Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

scientific article
Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo

scientific article published in 2008
A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway

scientific article (publication date: 8 November 2013)
Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains

scientific article published on December 1999
Gene organization of a Plasmodium falciparum serine hydroxymethyltransferase and its functional expression in Escherichia coli

scientific article published in October 2000
Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate

scientific article published in May 1993
Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli

scientific article published on June 1994
A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

scientific article (publication date: 9 December 2016)
Plasmodium falciparum:Kinetic Interactions of WR99210 with Pyrimethamine-Sensitive and Pyrimethamine-Resistant Dihydrofolate Reductase

scientific article published on November 1, 1997
Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

scientific article
Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum

scientific article published on December 1, 1994
Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694

scientific article
Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.

scientific article
Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications

scientific article
Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION

scientific article (publication date: 14 August 2015)
Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX

scientific article
Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase

scientific article published on 08 July 2009
Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice

scientific article published on July 1990

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