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List of works by Francesco Leone

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Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial

scientific article
Assessment of a HER2 scoring system for colorectal cancer: results from a validation study

scientific article published on 09 October 2015
Panitumumab in combination with gemcitabine and oxaliplatin does not prolong survival in wild-type KRAS advanced biliary tract cancer: A randomized phase 2 trial (Vecti-BIL study).

scientific article published on 5 November 2015
Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

scientific article published on 01 July 2018
Panitumumab in combination with infusional oxaliplatin and oral capecitabine for conversion therapy in patients with colon cancer and advanced liver metastases

scientific article published on July 18, 2013
Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation

scientific article published in January 2015
HER-2 inhibition in gastric and colorectal cancers: tangible achievements, novel acquisitions and future perspectives

scientific article published on 12 August 2016
Prognostic factors in 868 advanced gastric cancer patients treated with second-line chemotherapy in the real world.

scientific article published on 27 December 2016
Second-line chemotherapy for advanced pancreatic cancer: Which is the best option?

scientific article published on 20 April 2017
Antitumor Activity of Src Inhibitor Saracatinib (AZD-0530) in Preclinical Models of Biliary Tract Carcinomas

scientific article published on March 27, 2012
Predicting locally advanced rectal cancer response to neoadjuvant therapy with 18F-FDG PET and MRI radiomics features

scientific article published on 13 January 2019
Linifanib: current status and future potential in cancer therapy

scientific article published on 02 May 2015
The Immune Revolution in Gastrointestinal Tumours: Leading the Way or Just Following?

scientific article published on 17 May 2016
Aflibercept Plus FOLFIRI in the Real-life Setting: Safety and Quality of Life Data From the Italian Patient Cohort of the Aflibercept Safety and Quality-of-Life Program Study

scientific article published on 8 March 2018
Outcomes of Advanced Gastric Cancer Patients Treated with at Least Three Lines of Systemic Chemotherapy.

scientific article published on 31 August 2017
Potentially resectable metastatic colorectal cancer: an individualized approach to conversion therapy.

scientific article published on 08 June 2014
A validated prognostic classifier for V600EBRAF-mutated metastatic colorectal cancer: the 'BRAF BeCool' study

scientific article published on 19 July 2019
Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity

scientific article published on 5 May 2016
HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

scientific article published on 05 April 2019
Outcomes of Advanced Gastric Cancer Patients Treated with at Least Three Lines of Systemic Chemotherapy

scientific article published in February 2018
Tracking the 2015 Gastrointestinal Cancers Symposium: bridging cancer biology to clinical gastrointestinal oncology

scientific article
Gene and microRNA modulation upon trabectedin treatment in a human intrahepatic cholangiocarcinoma paired patient derived xenograft and cell line.

scientific article published on 24 November 2016
TRIPLETE: a randomised phase III study of modified FOLFOXIRI plus panitumumab versus mFOLFOX6 plus panitumumab as initial therapy for patients with unresectable and wild-type metastatic colorectal cancer

scientific article published on 09 July 2018
Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models

scientific article
Improvement of Metastatic Colorectal Cancer Patient Survival: Single Institution Experience

scientific article published on 15 March 2019
Successful treatment of gemcitabine-induced acute interstitial pneumonia with imatinib mesylate: a case report

scientific article
Estimating Survival Probabilities of Advanced Gastric Cancer Patients in the Second-Line Setting: The Gastric Life Nomogram

article
Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma.

scientific article published on 5 June 2018
Establishment and Characterization of a New Intrahepatic Cholangiocarcinoma Cell Line Resistant to Gemcitabine.

scientific article published on 11 April 2019
Assessment of a High Sensitivity Method for Identification of IDH1 R132x Mutations in Tumors and Plasma of Intrahepatic Cholangiocarcinoma Patients.

scientific article published on 30 March 2019
The prognostic nutritional index predicts survival and response to first-line chemotherapy in advanced biliary cancer

scientific article published on 11 December 2019
Bone metastases in biliary cancers: A multicenter retrospective survey

scientific article published on 07 April 2018
Prognostic and predictive role of EGFR pathway alterations in biliary cancer patients treated with chemotherapy and anti-EGFR.

scientific article published on 19 January 2018
"Shades of Gray" in pancreatic ductal adenocarcinoma: Reappraisals on resectability criteria: Debated indications for surgery in pancreatic cancer

scientific article published on 02 November 2018
Validated Nomogram Predicting 6-Month Survival in Pancreatic Cancer Patients Receiving First-Line 5-Fluorouracil, Oxaliplatin, and Irinotecan

scientific article published on 04 September 2019
Rationale for the use of metronomic chemotherapy in gastrointestinal cancer

scientific article published on 30 August 2018
Real-world gastric cancer patients treated with at least three lines of chemotherapy: Outcomes and predictors for efficacy

scientific article published on 01 June 2017
Is There a Standard Adjuvant Therapy for Resected Pancreatic Cancer?

scientific article published on 12 October 2019
Corrigendum to ""Shades of Gray" in pancreatic ductal adenocarcinoma: Reappraisals on resectability criteria: Debated indications for surgery in pancreatic cancer" [Crit. Rev. Oncol. Hematol. 133 (January) (2019) 17-24]

scientific article published on 12 February 2020
Pharmacotherapeutic options for biliary tract cancer: current standard of care and new perspectives

scientific article published on 24 September 2019
Quality of life assessment and reporting in colorectal cancer: a systematic review of phase 3 trials published between 2012 and 2018

scientific article published on 01 July 2019
Second-line treatment efficacy and toxicity in older vs. non-older patients with advanced gastric cancer: A multicentre real-world study

scientific article published on 11 December 2018
Selecting patients for gastrectomy in metastatic esophago-gastric cancer: clinics and pathology are not enough.

scientific article published on 4 October 2017
Prediction of Benefit from Checkpoint Inhibitors in Mismatch Repair Deficient Metastatic Colorectal Cancer: Role of Tumor Infiltrating Lymphocytes

scientific article published on 22 January 2020

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