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List of works by Franciszek K Główka

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Clinical pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases

scientific article published on February 2014
Pharmacokinetics of high-dose i.v. treosulfan in children undergoing treosulfan-based preparative regimen for allogeneic haematopoietic SCT.

scientific article published on October 2008
Genetic and non-genetic factors affecting the response to clopidogrel therapy

scientific article published on 07 March 2012
Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes

scientific article published in June 2009
High-dose treosulfan in conditioning prior to hematopoietic stem cell transplantation

scientific article published on October 1, 2010
High performance capillary electrophoresis for determination of the enantiomers of 2-arylpropionic acid derivatives in human serum. Pharmacokinetic studies of ketoprofen enantiomers following administration of standard and sustained release tablets.

scientific article
Impact of common ABCB1 polymorphism on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites

scientific article published on 28 November 2014
HPLC–MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples

scientific article published on 12 November 2012
Activation of Prodrug Treosulfan at pH 7.4 and 37°C Accompanied by Hydrolysis of Its Active Epoxides: Kinetic Studies with Clinical Relevance

scientific article published on 30 September 2015
Pharmacokinetics of treosulfan and its active monoepoxide in pediatric patients after intravenous infusion of high-dose treosulfan prior to HSCT.

scientific article published on 16 December 2014
HPLC method for determination of fluorescence derivatives of cortisol, cortisone and their tetrahydro- and allo-tetrahydro-metabolites in biological fluids

scientific article published on 26 November 2009
Impact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel

scientific article published on 18 February 2016
Glucocorticoid Metabolism in Hypertensive Disorders of Pregnancy: Analysis of Plasma and Urinary Cortisol and Cortisone.

scientific article published on 4 December 2015
Stereoselective pharmacokinetics of indobufen from tablets and intramuscular injections in man

scientific article published on 01 January 2000
Determination of partition coefficients n-octanol/water for treosulfan and its epoxy-transformers: An example of a negative correlation between lipophilicity of unionized compounds and their retention in reversed-phase chromatography

scientific article published on February 19, 2013
Resolution of indobufen enantiomers by capillary zone electrophoresis. Pharmacokinetic studies of human serum.

scientific article published in April 2004
The influence of genetic polymorphism of Cyp2c19 isoenzyme on the pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases

scientific article published on 06 May 2014
Kinetic and Mechanistic Study of the pH-Dependent Activation (Epoxidation) of Prodrug Treosulfan Including the Reaction Inhibition in a Borate Buffer

scientific article published on 22 March 2017
Increased cortisol metabolism in women with pregnancy-related hypertension.

scientific article published on 2 April 2018
LC procedure with SPE for quantification of indobufen enantiomers: pharmacokinetic studies

scientific article published on 01 February 2000
Determination of ketoprofen enantiomers in human serum by capillary zone electrophoresis: man pharmacokinetic studies after administration of rac-ketoprofen tablets

scientific article published in November 2002
Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation.

scientific article published on 3 October 2017
Penetration of Treosulfan and its Active Monoepoxide Transformation Product into Central Nervous System of Juvenile and Young Adult Rats.

scientific article
Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite.

scientific article published on 15 September 2017
HPLC method for determination of biologically active epoxy-transformers of treosulfan in human plasma: pharmacokinetic application

scientific article published on 24 December 2011
RP-HPLC method with fluorescence detection for determination of small quantities of triamcinolone in plasma in presence of endogenous steroids after derivatization with 9-anthroyl nitrile; pharmacokinetic studies

scientific article published on 23 March 2006
11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia

scientific article
Stereoselective pharmacokinetics of ibuprofen and its lysinate from suppositories in rabbits

scientific article published on 01 April 2000
HSD11B2, RUNX3, and LINE-1 Methylation in Placental DNA of Hypertensive Disorders of Pregnancy Patients.

scientific article
Ticagrelor in modern cardiology - an up-to-date review of most important aspects of ticagrelor pharmacotherapy

scientific article published on 27 December 2017
Direct high-performance liquid chromatography method with refractometric detection designed for stability studies of treosulfan and its biologically active epoxy-transformers.

scientific article published on 16 October 2012
Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of protein-free pro-drug treosulfan and its biologically active monoepoxy-transformer in plasma and brain tissue.

scientific article published on 4 April 2014
Enantioselective CE method for pharmacokinetic studies on ibuprofen and its chiral metabolites with reference to genetic polymorphism

scientific article published on 01 August 2007
Formation Rate-Limited Pharmacokinetics of Biologically Active Epoxy Transformers of Prodrug Treosulfan

scientific article published on 01 April 2016
Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives.

scientific article published on 19 March 2018
Determination of treosulfan in plasma and urine by HPLC with refractometric detection; pharmacokinetic studies in children undergoing myeloablative treatment prior to haematopoietic stem cell transplantation

scientific article published on 22 December 2006
11β-Hydroxysteroid dehydrogenase type 2 in hypertension: comparison of phenotype and genotype analysis

scientific article published on 10 January 2013
Modulatory effect of chiral nonsteroidal anti-inflammatory drugs on apoptosis of human neutrophils.

scientific article
Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis

scientific article
Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: Studies in a rat model with clinical relevance.

scientific article published on 12 September 2017
Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC-ESI-MS/MS method

scientific article published on 18 March 2017
Effect of Temperature on the Kinetics of the Activation of Treosulfan and Hydrolytic Decomposition of Its Active Epoxy Derivatives.

scientific article published on 6 June 2017
Steady-state pharmacokinetics of indobufen enantiomers in patients with obliterative atherosclerosis

scientific article published on June 2001
Bupivacaine administered intrathecally versus rectally in the management of intractable rectal cancer pain in palliative care

scientific article
Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MS.

scientific article published on 21 March 2017
Assessment of the Risk of Rhabdomyolysis and Myopathy During Concomitant Treatment with Ticagrelor and Statins

scientific article published on 01 July 2018
Protein binding of indobufen enantiomers: pharmacokinetics of free fraction-studies after single or multiple doses of rac-indobufen

scientific article published in October 2002
High performance capillary electrophoresis method for determination of ibuprofen enantiomers in human serum and urine

scientific article published in May 2005
Kinetics of in Vitro Guanine- N7-Alkylation in Calf Thymus DNA by (2 S,3 S)-1,2-Epoxybutane-3,4-diol 4-methanesulfonate and (2 S,3 S)-1,2:3,4-Diepoxybutane: Revision of the Mechanism of DNA Cross-Linking by the Prodrug Treosulfan

scientific article published on 03 May 2019
Lumbar paravertebral blockade as intractable pain management method in palliative care.

scientific article

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