List of works - Donna Neuberg

Age-related clonal hematopoiesis associated with adverse outcomes

scientific article

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

scientific article published on February 2013

Clinical effect of point mutations in myelodysplastic syndromes

scientific article

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl

scientific article published on February 2005

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

scientific article

An immunogenic personal neoantigen vaccine for patients with melanoma

scientific article

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

scientific article

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

scholarly article

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

article

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

scientific article published in August 2004

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

scholarly article

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

scientific article

Mutations driving CLL and their evolution in progression and relapse

scientific article published on 14 October 2015

Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.

scientific article published on 2 September 2004

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.

scientific article

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients

scientific article

Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy

scientific article published on 23 January 2012

Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells

scientific article published on September 2011

Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

scientific article

DHODH modulates transcriptional elongation in the neural crest and melanoma

scientific article

Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy.

scientific article published on 27 October 2009

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

scientific article

Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia

scientific article published on 24 June 2008

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

article

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.

scientific article

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

scientific article

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia

scientific article

Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry

scientific article

Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma.

scientific article published in September 2003

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

scientific article published on 19 December 2018

Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation

scientific article

Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia

scientific article

Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma

scientific article

Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation

scientific article published on February 2017

Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells

scientific article

NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes

scientific article

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

scientific article published on 20 June 2016

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

scholarly article

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility

scientific article

High-risk neuroblastoma treated with tandem autologous peripheral-blood stem cell-supported transplantation: long-term survival update

scientific article

Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.

scientific article published on September 2012

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

scientific article published on 20 May 2016

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia

scientific article published on 30 August 2005

Phase II Study of Dasatinib in Relapsed or Refractory Chronic Lymphocytic Leukemia

scientific article published on March 14, 2011

Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity

scientific article published on 20 October 2005

Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays

scientific article published on 28 February 2007

Establishment of Antitumor Memory in Humans Using in Vitro–Educated CD8 + T Cells

scientific article published on April 27, 2011

The frequency and management of asparaginase‐related thrombosis in paediatric and adult patients with acute lymphoblastic leukaemia treated on Dana‐Farber Cancer Institute consortium protocols

scientific article published on January 7, 2011

Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarrays

scientific article

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.

scientific article

List of works by Donna Neuberg

Age-related clonal hematopoiesis associated with adverse outcomes

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

Clinical effect of point mutations in myelodysplastic syndromes

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

An immunogenic personal neoantigen vaccine for patients with melanoma

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

Mutations driving CLL and their evolution in progression and relapse

Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients

Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy

Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells

Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

DHODH modulates transcriptional elongation in the neural crest and melanoma

Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy.

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia

Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry

Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma.

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation

Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia

Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma

Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation

Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells

NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility

High-risk neuroblastoma treated with tandem autologous peripheral-blood stem cell-supported transplantation: long-term survival update

Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia

Phase II Study of Dasatinib in Relapsed or Refractory Chronic Lymphocytic Leukemia

Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity

Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays

Establishment of Antitumor Memory in Humans Using in Vitro–Educated CD8 + T Cells

The frequency and management of asparaginase‐related thrombosis in paediatric and adult patients with acute lymphoblastic leukaemia treated on Dana‐Farber Cancer Institute consortium protocols

Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarrays

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.