List of works - Alessandra Boletta

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

scientific article (publication date: December 2000)

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

scientific journal article

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

scientific article

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

scientific article published on 24 March 2013

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

scientific article

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

scientific article published on 2 March 2009

Nonviral Gene Delivery to the Rat Kidney with Polyethylenimine

article

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

scientific article

Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion

scientific article

Role of polycystins in renal tubulogenesis

scientific article (publication date: September 2003)

Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases

scientific article published on 24 May 2010

A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.

scientific article

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

scientific article

Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway.

scientific article

2-Deoxy-d-Glucose Ameliorates PKD Progression

scientific article

Emerging evidence of a link between the polycystins and the mTOR pathways

scientific article published on 28 October 2009

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

scientific article

Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling

scientific article

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis

scientific article published on January 2013

The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function

scientific article

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

scientific article published on 2 March 2016

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.

scientific article published in August 2015

Biochemical characterization of bona fide polycystin-1 in vitro and in vivo

scientific article published on 01 December 2001

Defective metabolism in polycystic kidney disease: potential for therapy and open questions

scientific article published on January 23, 2014

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

scientific article published on 23 January 2014

Metabolism and mitochondria in polycystic kidney disease research and therapy

scientific article published on 01 November 2018

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells

scientific article

Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals

scientific article

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

scientific article published on 13 August 2015

Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease

scientific article

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

scientific article

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

scientific article

A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression

scientific article published on 14 August 2006

Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

scientific article published on 8 August 2016

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

scientific article

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

scientific article

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells

scientific article published on 9 June 2016

Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways

scientific article published on 16 November 2018

Defective glycolysis and the use of 2-deoxy-D-glucose in polycystic kidney disease: from animal models to humans.

scientific article published on 7 April 2017

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.

scientific article

Glomerular filtration is required for transfection of proximal tubular cells in the rat kidney following injection of DNA complexes into the renal artery

scientific article

mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma

scientific article published on 01 July 2018

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets

scientific article

Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

scientific article published on 06 December 2019

Individualized anticoagulation with dermatan sulphate for haemodialysis in chronic renal failure

scientific article published on November 1, 1997

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

scientific article published on 14 March 2018

Slowing Polycystic Kidney Disease by Fasting

scientific article published on November 4, 2015

The N-Terminal Domain of NPHP1 Folds into a Monomeric Left-Handed Antiparallel Three-Stranded Coiled Coil with Anti-apoptotic Function

scientific article published on 05 August 2019

Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?

scientific article published on 13 July 2020

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

scientific article published on 12 November 2019

List of works by Alessandra Boletta

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

Nonviral Gene Delivery to the Rat Kidney with Polyethylenimine

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion

Role of polycystins in renal tubulogenesis

Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases

A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway.

2-Deoxy-d-Glucose Ameliorates PKD Progression

Emerging evidence of a link between the polycystins and the mTOR pathways

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis

The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.

Biochemical characterization of bona fide polycystin-1 in vitro and in vivo

Defective metabolism in polycystic kidney disease: potential for therapy and open questions

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

Metabolism and mitochondria in polycystic kidney disease research and therapy

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells

Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression

Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells

Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways

Defective glycolysis and the use of 2-deoxy-D-glucose in polycystic kidney disease: from animal models to humans.

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.

Glomerular filtration is required for transfection of proximal tubular cells in the rat kidney following injection of DNA complexes into the renal artery

mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets

Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

Individualized anticoagulation with dermatan sulphate for haemodialysis in chronic renal failure

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

Slowing Polycystic Kidney Disease by Fasting

The N-Terminal Domain of NPHP1 Folds into a Monomeric Left-Handed Antiparallel Three-Stranded Coiled Coil with Anti-apoptotic Function

Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness