List of works - Jane A Endicott

Protein kinase inhibitors: insights into drug design from structure.

scientific article published on March 2004

The structural basis for control of eukaryotic protein kinases

scientific article published on 05 April 2012

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3

scientific article

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP

scientific article

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

scientific article

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

scientific article published on September 2005

How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.

scientific article published on 9 November 2006

Structures of the Dsk2 UBL and UBA domains and their complex

scientific article

A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway

scientific article

Recent developments in cyclin-dependent kinase biochemical and structural studies.

scientific article published on 12 October 2009

Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

scientific article

Halogen bonds form the basis for selective P-TEFb inhibition by DRB

scientific article

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

scientific article published in January 2003

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency

scientific article published on 11 February 2011

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

scientific article

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

scientific article

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12

scientific article

Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases

scientific article

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

scientific article

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.

scientific article published on 31 January 2008

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.

scientific article published on 13 April 2015

Cyclin-dependent kinase homologues of Plasmodium falciparum

scientific article

Structure-based design of cyclin-dependent kinase inhibitors

scientific article

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

scientific article

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

scientific article

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2

scientific article

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction

scientific article published in November 2008

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

scientific article

Structural characterization of the cyclin-dependent protein kinase family

scientific article published on August 1, 2013

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

scientific article

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

scientific article

Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family

scientific article published on January 1, 1991

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

scientific article

Budding yeast Dsk2 protein forms a homodimer via its C-terminal UBA domain

scientific article published in October 2005

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

scientific article

Exploiting structural principles to design cyclin-dependent kinase inhibitors.

scientific article

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

scientific article

A new crystal form of Lys48-linked diubiquitin

scientific article

The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant

scientific article

Identification and Characterization of an Irreversible Inhibitor of CDK2.

scientific article published on 27 August 2015

Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity

scientific article

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

scientific article

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.

scientific article

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

scientific article published on 22 December 2016

An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.

scientific article

Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy

scientific article published on March 2011

Structural principles in cell-cycle control: beyond the CDKs

scientific article published on May 15, 1998

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System.

scientific article published in October 2017

Methods for preparation of proteins and protein complexes that regulate the eukaryotic cell cycle for structural studies.

scientific article

Structural insights into the functional diversity of the CDK-cyclin family

scientific article published on 01 September 2018

List of works by Jane A Endicott

Protein kinase inhibitors: insights into drug design from structure.

The structural basis for control of eukaryotic protein kinases

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.

Structures of the Dsk2 UBL and UBA domains and their complex

A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway

Recent developments in cyclin-dependent kinase biochemical and structural studies.

Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

Halogen bonds form the basis for selective P-TEFb inhibition by DRB

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12

Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.

Cyclin-dependent kinase homologues of Plasmodium falciparum

Structure-based design of cyclin-dependent kinase inhibitors

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

Structural characterization of the cyclin-dependent protein kinase family

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

Budding yeast Dsk2 protein forms a homodimer via its C-terminal UBA domain

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

Exploiting structural principles to design cyclin-dependent kinase inhibitors.

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

A new crystal form of Lys48-linked diubiquitin

The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant

Identification and Characterization of an Irreversible Inhibitor of CDK2.

Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.

Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy

Structural principles in cell-cycle control: beyond the CDKs

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System.

Methods for preparation of proteins and protein complexes that regulate the eukaryotic cell cycle for structural studies.

Structural insights into the functional diversity of the CDK-cyclin family