List of works - K-U Wagner

Cre-mediated gene deletion in the mammary gland

scientific article published on November 1, 1997

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

scientific article

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

scientific article published on November 12, 2001

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

scientific article

Erythropoietin protects against diabetes through direct effects on pancreatic β cells

scientific article published on December 13, 2010

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling

scientific article published on October 25, 2010

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

scientific article published on October 2011

Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.

scientific article

Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer

scientific journal article

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

scientific journal article

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

scientific article published on 6 March 2013

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

scientific article published on 27 March 2013

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.

scientific article

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

scientific article published on June 2012

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.

scientific article published on 10 February 2017

Jak2 is necessary for neuroendocrine control of female reproduction

scientific article

Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.

scientific article

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells.

scientific article

Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance

scientific article published on January 24, 2012

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.

scientific article published on 20 December 2012

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

scientific article

Human prolactin receptors are insensitive to mouse prolactin: implications for xenotransplant modeling of human breast cancer in mice.

scientific article

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

scientific article published on 2 April 2013

IRF4 is a suppressor of c-Myc induced B cell leukemia.

scientific article

Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia.

scientific article published on 7 February 2014

D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells

scientific article published on April 4, 2013

Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.

scientific article published on 6 June 2013

Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies

scientific article published on 26 March 2014

Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.

scientific article published on 27 January 2014

Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression

scientific article published on October 28, 2011

Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species

scientific article published on February 24, 2011

Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.

scientific article

A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.

scientific article

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

scientific article published on 04 April 2016

Cyr61 as mediator of Src signaling in triple negative breast cancer cells.

scientific article

Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.

scientific article

Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.

scientific article published on April 2009

Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.

scientific article

A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.

scientific article published on December 2008

Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax

scientific article published on 03 January 2011

Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.

scientific article

Generation of a Novel MMTV-tTA Transgenic Mouse Strain for the Targeted Expression of Genes in the Embryonic and Postnatal Mammary Gland

scientific article published on August 31, 2012

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers

scientific article

Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.

scientific article

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

scientific article published on 7 October 2016

Generation of Janus kinase 1 (JAK1) conditional knockout mice.

scientific article published on 27 September 2016

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

scientific article

ESCRT proteins: Double-edged regulators of cellular signaling

scientific article published on January 1, 2011

Generation of conditional knockout mice.

scientific article published in January 2014

Genetically engineered mucin mouse models for inflammation and cancer.

scientific article published on 30 January 2015

List of works by K-U Wagner

Cre-mediated gene deletion in the mammary gland

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

Erythropoietin protects against diabetes through direct effects on pancreatic β cells

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.

Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.

Jak2 is necessary for neuroendocrine control of female reproduction

Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells.

Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

Human prolactin receptors are insensitive to mouse prolactin: implications for xenotransplant modeling of human breast cancer in mice.

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

IRF4 is a suppressor of c-Myc induced B cell leukemia.

Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia.

D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells

Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.

Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies

Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.

Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression

Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species

Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.

A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

Cyr61 as mediator of Src signaling in triple negative breast cancer cells.

Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.

Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.

Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.

A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.

Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax

Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.

Generation of a Novel MMTV-tTA Transgenic Mouse Strain for the Targeted Expression of Genes in the Embryonic and Postnatal Mammary Gland

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers

Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

Generation of Janus kinase 1 (JAK1) conditional knockout mice.

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

ESCRT proteins: Double-edged regulators of cellular signaling

Generation of conditional knockout mice.

Genetically engineered mucin mouse models for inflammation and cancer.