List of works - Sandra L Siedlak

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

scholarly article

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

scientific article published in March 2003

Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment

scientific article

Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation

scientific article published on May 1, 2003

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

scientific article

Autophagocytosis of mitochondria is prominent in Alzheimer disease

scientific article

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

scientific article published on 27 June 2016

Vascular oxidative stress in Alzheimer disease

scientific article

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

scientific article

Neurofilament proteins in neurodegenerative diseases

scientific article

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

scientific article published in February 2002

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

scientific article published on 23 April 2008

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

scientific article

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

scientific article published on 21 August 2013

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

scientific article published on 3 December 2001

c-Jun phosphorylation in Alzheimer disease

scientific article

Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material

scientific article published in June 2008

Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice

scientific article published on September 2003

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

scientific article published on April 2009

Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

scientific article

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

scientific article

Redox metals and oxidative abnormalities in human prion diseases

scientific article published on 11 August 2005

Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis

scientific article

Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

scientific article

MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons*

scientific article published on November 21, 2014

A metabolic basis for Alzheimer disease

scientific article published on October 2003

Oxidative damage to nucleic acids in human prion disease

scientific article published in April 2002

Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?

scientific article

LRRK2 protein is a component of lewy bodies

Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions

scientific article published in August 2006

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

scientific article published on February 2009

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure

scientific article

Posttranslational modifications of α-tubulin in alzheimer disease

scientific article

A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules

scientific article

LRRK2 in Parkinson's disease and dementia with Lewy bodies

scientific article

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

scientific article published on 23 July 2009

Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease

scientific article published on February 1, 1992

Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease

scientific article

Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model

scientific article

Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease

scientific article published on 22 January 2007

Neuroprotective properties of Bcl-w in Alzheimer disease

scientific article

Miro1 deficiency in amyotrophic lateral sclerosis

scientific article published on 26 May 2015

Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.

scientific article published on January 2008

The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.

scientific article published in September 2002

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain

scientific article published on 18 October 2013

Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation

scientific article published on March 16, 2016

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

scientific article

Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis

scientific article published on October 30, 2010

Compensatory responses induced by oxidative stress in Alzheimer disease

scientific article

Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: a population-based study

scientific article

List of works by Sandra L Siedlak

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment

Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

Autophagocytosis of mitochondria is prominent in Alzheimer disease

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

Vascular oxidative stress in Alzheimer disease

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

Neurofilament proteins in neurodegenerative diseases

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

c-Jun phosphorylation in Alzheimer disease

Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material

Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

Redox metals and oxidative abnormalities in human prion diseases

Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis

Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons*

A metabolic basis for Alzheimer disease

Oxidative damage to nucleic acids in human prion disease

Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?

LRRK2 protein is a component of lewy bodies

Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure

Posttranslational modifications of α-tubulin in alzheimer disease

A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules

LRRK2 in Parkinson's disease and dementia with Lewy bodies

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease

Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease

Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model

Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease

Neuroprotective properties of Bcl-w in Alzheimer disease

Miro1 deficiency in amyotrophic lateral sclerosis

Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.

The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain

Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis

Compensatory responses induced by oxidative stress in Alzheimer disease

Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: a population-based study