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List of works by Guy A Caldwell

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

scientific article
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

scholarly article
Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

scientific article published in April 2005
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

scientific article
Lysosomal impairment in Parkinson's disease

scientific article published on 11 April 2013
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

scientific article published on June 2006
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

scientific article
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

scientific article published on January 2014
Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins

scientific article published in February 2003
MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain

scientific article published in November 2004
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

scientific article published on July 18, 2011
TorsinA participates in endoplasmic reticulum-associated degradation

scientific article
The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response

scientific article
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.

scientific article
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

scientific article published on May 29, 2012
C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.

scientific article published on May 2010
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

scientific article published on 22 January 2014
VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.

scientific article published on 20 October 2009
Generation of stable transgenic C. elegans using microinjection

scientific article
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans

scientific article published on 14 July 2004
The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro

scientific article
Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction.

scientific article
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease

scientific article
Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease

scientific article published on September 8, 2014
Chemical enhancement of torsinA function in cell and animal models of torsion dystonia

scientific article
Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration

scientific article
Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.

scientific article published on February 2012
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.

scientific article
Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases

scientific article published on 3 July 2013
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans

scientific article published on 22 September 2006
Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids

scientific article published on 10 February 2004
RTCB-1 Mediates Neuroprotection via XBP-1 mRNA Splicing in the Unfolded Protein Response Pathway

scientific article published on November 26, 2014
A Predictable Worm: Application of Caenorhabditis elegans for Mechanistic Investigation of Movement Disorders

scientific article published on April 1, 2012
Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.

scientific article published on 18 July 2008
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

scientific article
The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro

scientific article published on 15 July 2008
Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.

scientific article published on 21 September 2009
Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.

scientific article published on 13 October 2017
C. elegans as a model system to accelerate discovery for Parkinson disease

scientific article published on 24 February 2017
TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS

scientific article published on 05 December 2013
Modeling dopamine neuron degeneration in Caenorhabditis elegans

article published in 2011
Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants.

scientific article
Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation

scientific article published on 30 July 2007
Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling

scientific article published on February 26, 2013
The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity

scientific article published on 10 February 2018
Animal models for drug discovery in dystonia

scientific article published on January 1, 2008
Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease

scientific article published on 31 December 2010
Genetic and Pharmacological Discovery for Alzheimer's Disease Using Caenorhabditis elegans.

scientific article published on 12 October 2017
Phenazine derivatives cause proteotoxicity and stress in C. elegans

scientific article published on October 7, 2014
NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease

scientific article published in October 2017

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