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Authors whose works are in public domain in at least one jurisdiction

List of works by Leen Delang

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Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein

scientific article
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

scientific article
Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development

scientific article published on July 2009
The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination

scientific article
Favipiravir as a potential countermeasure against neglected and emerging RNA viruses

scientific article
The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication

scientific article published on 08 August 2012
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

scientific article
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication

scientific article published on 7 December 2012
Comparative study of the genetic barriers and pathways towards resistance of selective inhibitors of hepatitis C virus replication

scientific article
Chikungunya virus infections: time to act, time to treat

scientific article
The future of antivirals: broad-spectrum inhibitors

scientific article
Hepatitis C virus-specific directly acting antiviral drugs

scientific article published on January 2013
Antiviral therapy for hepatitis C virus: beyond the standard of care

scientific article published on 29 March 2010
Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals

scientific article published on 20 July 2017
Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

scientific article
Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication

scientific article
Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication

scientific article
Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication

scientific article published on 28 May 2014
Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication

scientific article published on 13 May 2015
Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

scientific article published on 5 April 2017
Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway

scientific article published on 22 February 2016
Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

scientific article published on 12 June 2017
Antiviral Strategies Against Chikungunya Virus

scientific article published on January 2016
Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection

scientific article published on 25 September 2017
Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death

scientific article published on 22 February 2016
In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors

scientific article published on 20 May 2011
Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase

scientific article
Antiplasmodial, Anti-chikungunya virus and Antioxidant Activities of 64 endemic Plants from the Mascarene Islands

article
Are statins a viable option for the treatment of infections with the hepatitis C virus?

scientific article published on 6 March 2014
New class of early-stage enterovirus inhibitors with a novel mechanism of action

scientific article published on 6 October 2017
Protein kinases C as potential host targets for the inhibition of chikungunya virus replication

scientific article
A Viral Polymerase Inhibitor Reduces Zika Virus Replication in the Reproductive Organs of Male Mice

scientific article
Differential Transmission of Antiviral Drug-Resistant Chikungunya Viruses by Mosquitoes

scientific article published in 2018
Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication

scientific article published on 31 October 2016
Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism

scientific article published on 21 September 2016
Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors

scientific article published on 16 January 2016
Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents

scientific article published on 6 January 2018
Glutathione is a highly efficient thermostabilizer of poliovirus Sabin strains

scientific article published on 8 February 2017
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

scientific article
Selecting and characterizing drug-resistant hepatitis C virus replicon

scientific article published on January 2013
PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases

scholarly article by Leen Delang et al published 14 September 2018 in Journal of Antimicrobial Chemotherapy
Reaching beyond HIV/HCV: nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus

article
Mevastatin Markedly Potentiates the Anti-HCV Activity of Selective Inhibitors of HCV Replication and Delays or Prevents the Emergence of Antiviral Resistance

scientific article published in 2008
Reply:

Understanding the molecular mechanism of host-based statin resistance in hepatitis C virus replicon containing cells

scientific article published on 9 June 2015
Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

scientific article published on 23 February 2018
Comparative Study of the Genetic Barrier and Pathways Towards Resistance of Selective Inhibitors of HCV Replication

scientific article published in 2009
In Vitro Selection and Characterization of Hepatitis C Virus Replicons Double or Triple Resistant to Various Non-nucleoside HCV Polymerase Inhibitors

scientific article published in 2010

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