List of works - Ype Elgersma

Neurofibromin regulation of ERK signaling modulates GABA release and learning

scientific article

Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.

scientific article

Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.

scientific article

The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins.

scientific article

Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses

scientific article published on September 19, 2003

Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.

scientific article

PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae

scientific article published on December 1993

Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.

scientific article published in April 2003

Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning

scientific article

Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane

scientific article published in December 1997

Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway

scientific article

Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial

scientific article

Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition.

scientific article published in September 2004

DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2

scientific article published on July 25, 1991

Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors.

scientific article published in May 2008

Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene.

scientific article

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model.

scientific article published on 13 April 2015

Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells.

scientific article

βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses.

scientific article

Molecular mechanisms of synaptic plasticity and memory.

scientific article

A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris.

scientific article

Spred1 is required for synaptic plasticity and hippocampus-dependent learning

scientific article

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

scientific article published in August 2011

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility

scientific article published on 22 March 2016

Rheb is essential for murine development

scientific article

Proteins involved in peroxisome biogenesis and functioning.

scientific article

Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II.

scientific article published on August 2005

Impact of neurofibromatosis type 1 on school performance.

scientific article published in September 2008

TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice.

scientific article published on 10 September 2013

Analysis of Cx36 knockout does not support tenet that olivary gap junctions are required for complex spike synchronization and normal motor performance.

scientific article

Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome.

scientific article published on 9 July 2012

Quantitative differentiation between healthy and disordered brain matter in patients with neurofibromatosis type I using diffusion tensor imaging.

scientific article published on 13 March 2008

HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1.

scientific article published on 28 April 2015

Marked Reduction of AKT1 Expression and Deregulation of AKT1-Associated Pathways in Peripheral Blood Mononuclear Cells of Schizophrenia Patients

scientific article published on February 29, 2012

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

scientific article published in November 2017

Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses.

scientific article

CaMKII Regulates Oligodendrocyte Maturation and CNS Myelination

scientific article published on June 19, 2013

Cytosolic aspartate aminotransferase encoded by the AAT2 gene is targeted to the peroxisomes in oleate-grown Saccharomyces cerevisiae.

scientific article

Treatment of neurodevelopmental disorders in adulthood

scientific article

Synaptic transmission and plasticity at inputs to murine cerebellar Purkinje cells are largely dispensable for standard nonmotor tasks.

scientific article published on July 2013

Arc expression identifies the lateral amygdala fear memory trace.

scientific article

Temporal and region-specific requirements of αCaMKII in spatial and contextual learning.

scientific article

Interaction of SH-SY5Y cells with nanogratings during neuronal differentiation: comparison with primary neurons.

scientific article published on October 2013

Motor Learning in Children with Neurofibromatosis Type I

scientific article published on March 1, 2011

alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus.

scientific article published on 12 October 2007

Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model

scientific article published on October 20, 2015

Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum.

scientific article

The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research.

scientific article published on 20 July 2012

Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability

scientific article published on 20 October 2017

In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome

scientific article

List of works by Ype Elgersma

Neurofibromin regulation of ERK signaling modulates GABA release and learning

Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.

Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.

The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins.

Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses

Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.

PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae

Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.

Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning

Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane

Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway

Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial

Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition.

DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2

Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors.

Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene.

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model.

Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells.

βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses.

Molecular mechanisms of synaptic plasticity and memory.

A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris.

Spred1 is required for synaptic plasticity and hippocampus-dependent learning

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility

Rheb is essential for murine development

Proteins involved in peroxisome biogenesis and functioning.

Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II.

Impact of neurofibromatosis type 1 on school performance.

TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice.

Analysis of Cx36 knockout does not support tenet that olivary gap junctions are required for complex spike synchronization and normal motor performance.

Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome.

Quantitative differentiation between healthy and disordered brain matter in patients with neurofibromatosis type I using diffusion tensor imaging.

HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1.

Marked Reduction of AKT1 Expression and Deregulation of AKT1-Associated Pathways in Peripheral Blood Mononuclear Cells of Schizophrenia Patients

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses.

CaMKII Regulates Oligodendrocyte Maturation and CNS Myelination

Cytosolic aspartate aminotransferase encoded by the AAT2 gene is targeted to the peroxisomes in oleate-grown Saccharomyces cerevisiae.

Treatment of neurodevelopmental disorders in adulthood

Synaptic transmission and plasticity at inputs to murine cerebellar Purkinje cells are largely dispensable for standard nonmotor tasks.

Arc expression identifies the lateral amygdala fear memory trace.

Temporal and region-specific requirements of αCaMKII in spatial and contextual learning.

Interaction of SH-SY5Y cells with nanogratings during neuronal differentiation: comparison with primary neurons.

Motor Learning in Children with Neurofibromatosis Type I

alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus.

Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model

Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum.

The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research.

Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability

In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome