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List of works by Clive Holmes

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

scientific article
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scientific article
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)
Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

scientific article
Microglia in neurodegenerative disease

scientific article published on March 16, 2010
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

scientific article published on 17 March 2003
Microglial priming in neurodegenerative disease

scientific article published on 18 March 2014
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article
Donepezil and memantine for moderate-to-severe Alzheimer's disease.

scientific article
Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study

scientific article published in April 2007
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

scientific article (publication date: 15 November 2010)
Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

scientific article
Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial

scientific article published on 19 July 2011
Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease.

scientific article
Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I.

scientific article published on 7 November 2007
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling

scientific article (publication date: August 2009)
A novel Alzheimer disease locus located near the gene encoding tau protein.

scientific article
Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization

scientific article published on 13 August 2013
Common polygenic variation enhances risk prediction for Alzheimer's disease

scientific article published on 21 October 2015
Phase 3 trial of flutemetamol labeled with radioactive fluorine 18 imaging and neuritic plaque density.

scientific article published in March 2015
Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy

scientific article published on 22 January 2010
Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis.

scientific article published on 15 July 2010
Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

scientific article published on May 2015
Proinflammatory cytokines, sickness behavior, and Alzheimer disease

scientific article published on July 13, 2011
Periodontitis and Cognitive Decline in Alzheimer's Disease.

scientific article
Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study

scientific article published in July 2001
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

scientific article
Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study.

scientific article published in April 2002
Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses.

scientific article published on 26 October 2015
Targeting innate immunity for neurodegenerative disorders of the central nervous system

scientific article
Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease

scientific article
Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial).

scientific article
Microglial alterations in human Alzheimer's disease following Aβ42 immunization.

scientific article published in August 2011
A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease

scientific article published on 19 February 2011
Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation

scientific article
Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease

scientific article
Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.

scientific article
The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

scientific article
Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology

scientific article
Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease.

scientific article published in January 2004
Depression in Alzheimer's disease: the effect of serotonin receptor gene variation

scientific article published in May 2003
CAG/CTG repeat expansions at the Huntington's disease-like 2 locus are rare in Huntington's disease patients

scientific article
Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies

scientific article published in December 2001
Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

scientific article published in November 2008
DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT

scientific article published on 24 July 2009
Aβ immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy.

scientific article published on 7 September 2014
A randomised placebo controlled study to assess the effects of cholinergic treatment on muscarinic receptors in Alzheimer's disease

scientific article published on November 1, 2003
SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family

scientific article
Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease

scientific article published on 7 January 2015

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