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List of works by Mechthild Krause

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Exploring the role of cancer stem cells in radioresistance

scientific article
β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

scientific article
Radiation oncology in the era of precision medicine.

scientific article published on 18 March 2016
Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells

scientific article
Three-dimensional cell growth confers radioresistance by chromatin density modification

scientific article
EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms

scientific article published on 14 May 2007
Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments

scientific article
CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG).

scientific article
A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia

scientific article
ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer

scientific article published on 24 January 2015
Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results

scientific article published in September 2004
HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology G

scientific article published on 2 December 2014
Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC)

scientific article published on 13 July 2011
EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks

scientific article published on 18 August 2011
Cancer stem cells at the crossroads of current cancer therapy failures--radiation oncology perspective

scientific article published on 26 February 2010
Cancer stem cells: targets and potential biomarkers for radiotherapy

scientific article
Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining

scientific article
Simultaneous β1 integrin-EGFR targeting and radiosensitization of human head and neck cancer

scientific article
Cetuximab attenuates its cytotoxic and radiosensitizing potential by inducing fibronectin biosynthesis

scientific article published on 15 August 2013
Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression

scientific article published on 12 June 2011
CD44: A Cancer Stem Cell–Related Biomarker with Predictive Potential for Radiotherapy

scientific article published on September 22, 2010
Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma.

scientific article published on May 2007
Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies.

scientific article published on 7 September 2006
Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation.

scientific article
Cancer stem cells and radiotherapy.

scientific article published on May 2009
Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation

scientific article published on August 2005
Creating a data exchange strategy for radiotherapy research: towards federated databases and anonymised public datasets

scientific article
EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation

scientific article
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells.

scientific article published on 15 June 2015
Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG.

scientific article published on 11 January 2016
Radiotherapy and "new" drugs-new side effects?

scientific article
A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling.

scientific article published on 16 October 2017
Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy.

scientific article published on 17 August 2006
Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential

scientific article published on 16 January 2014
DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity

scientific article
Different classes of EGFR inhibitors may have different potential to improve local tumour control after fractionated irradiation: a study on C225 in FaDu hSCC.

scientific article published on 25 November 2004
HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Rad

scientific article published on 29 November 2016
Radiosensitization of NSCLC cells by EGFR inhibition is the result of an enhanced p53-dependent G1 arrest

scientific article
Spatial distribution of FMISO in head and neck squamous cell carcinomas during radio-chemotherapy and its correlation to pattern of failure.

scientific article published on 23 September 2015
Human gastric cancer modelling using organoids

scientific article published on 27 April 2018
Pre-clinical research in small animals using radiotherapy technology--a bidirectional translational approach

scientific article
Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma

scientific article
Radiolabeled Cetuximab Conjugates for EGFR Targeted Cancer Diagnostics and Therapy

scientific article published on 05 March 2014
Proliferation and micromilieu during fractionated irradiation of human FaDu squamous cell carcinoma in nude mice

scientific article published on July 1, 2003
Identification of Patient Benefit From Proton Therapy for Advanced Head and Neck Cancer Patients Based on Individual and Subgroup Normal Tissue Complication Probability Analysis

scientific article published on 23 April 2015
Individualization of cancer treatment from radiotherapy perspective

scientific article published on 09 February 2012
ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer, version 1.1.

scientific article published on 18 January 2016
Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: differences between antibodies and TK inhibitors

scientific article
EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: differential response of cancer stem cells and nontumourigenic cells?

scientific article published on 24 May 2007
The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair

scientific article

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