List of works - William C Copeland

Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

scientific article published on October 1, 2003

Mitochondrial DNA in human malignancy.

scientific article

Eukaryotic DNA polymerases: proposal for a revised nomenclature.

scientific article

Inherited mitochondrial diseases of DNA replication

scientific article

Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma

scientific article

DNA polymerase gamma in mitochondrial DNA replication and repair.

scientific article

The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance

scientific article

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia

scientific article

Characterization of the Native and Recombinant Catalytic Subunit of Human DNA Polymerase γ: Identification of Residues Critical for Exonuclease Activity and Dideoxynucleotide Sensitivity

scientific article published on July 21, 1998

The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit

scientific article published on 14 August 2001

Molecular and clinical genetics of mitochondrial diseases due to POLG mutations

scientific article

Mitochondrial DNA alterations in cancer.

scientific article

Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro

scientific article published on October 13, 1998

Long patch base excision repair in mammalian mitochondrial genomes

scientific article published on 17 July 2008

Defects in mitochondrial DNA replication and human disease

scientific article published on January 1, 2012

DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

scientific article

Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.

scientific article published on 19 February 2006

The common A467T mutation in the human mitochondrial DNA polymerase (POLG) compromises catalytic efficiency and interaction with the accessory subunit.

scientific article published on 16 July 2005

Consequences of mutations in human DNA polymerase gamma.

scientific article

DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations.

scientific article published on 29 October 2008

Mitochondria, energetics, epigenetics, and cellular responses to stress

scientific article

Molecular diagnosis of Alpers syndrome.

scientific article published on 20 February 2006

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations

scientific article

Mitochondrial genome maintenance in health and disease.

scientific article

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

scientific article

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

scientific article published on March 2006

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

scientific article

Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders

scientific article published on 6 November 2006

Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors.

scientific article published on 20 February 2006

Mitochondrial DNA polymerase gamma is expressed and translated in the absence of mitochondrial DNA maintenance and replication

scientific article

Human mitochondrial DNA replication machinery and disease

scientific article published on 08 April 2016

Reduction in frataxin causes progressive accumulation of mitochondrial damage.

scientific article published on 21 October 2003

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.

scientific article

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

scientific article published on 30 April 2016

Biochemical analysis of human POLG2 variants associated with mitochondrial disease.

scientific article

Mitochondrial Disease Sequence Data Resource (MSeqDR): a global grass-roots consortium to facilitate deposition, curation, annotation, and integrated analysis of genomic data for the mitochondrial disease clinical and research communities

scientific article (publication date: March 2015)

Ribonucleotide discrimination and reverse transcription by the human mitochondrial DNA polymerase.

scientific article

Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.

scientific article

Clinical and molecular features of POLG-related mitochondrial disease.

scientific article published on April 2013

Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine.

scientific article published on 16 January 2004

DNA polymerase gamma in mitochondrial DNA replication and repair

scientific article published on 17 March 2003

Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance

scientific journal article

mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae

scientific article

Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.

scientific article published in April 2007

The mitochondrial DNA polymerase in health and disease.

scientific article published on January 2010

Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome.

scientific article published on 21 September 2005

Progressive external ophthalmoplegia and vision and hearing loss in a patient with mutations in POLG2 and OPA1.

scientific article published on January 2008

R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity

scientific article published on 13 April 2009

The interface of transcription and DNA replication in the mitochondria

scientific article published on 20 December 2011

Defects of mitochondrial DNA replication.

scientific article

List of works by William C Copeland

Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

Mitochondrial DNA in human malignancy.

Eukaryotic DNA polymerases: proposal for a revised nomenclature.

Inherited mitochondrial diseases of DNA replication

Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma

DNA polymerase gamma in mitochondrial DNA replication and repair.

The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia

Characterization of the Native and Recombinant Catalytic Subunit of Human DNA Polymerase γ: Identification of Residues Critical for Exonuclease Activity and Dideoxynucleotide Sensitivity

The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit

Molecular and clinical genetics of mitochondrial diseases due to POLG mutations

Mitochondrial DNA alterations in cancer.

Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro

Long patch base excision repair in mammalian mitochondrial genomes

Defects in mitochondrial DNA replication and human disease

DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.

The common A467T mutation in the human mitochondrial DNA polymerase (POLG) compromises catalytic efficiency and interaction with the accessory subunit.

Consequences of mutations in human DNA polymerase gamma.

DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations.

Mitochondria, energetics, epigenetics, and cellular responses to stress

Molecular diagnosis of Alpers syndrome.

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations

Mitochondrial genome maintenance in health and disease.

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders

Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors.

Mitochondrial DNA polymerase gamma is expressed and translated in the absence of mitochondrial DNA maintenance and replication

Human mitochondrial DNA replication machinery and disease

Reduction in frataxin causes progressive accumulation of mitochondrial damage.

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

Biochemical analysis of human POLG2 variants associated with mitochondrial disease.

Mitochondrial Disease Sequence Data Resource (MSeqDR): a global grass-roots consortium to facilitate deposition, curation, annotation, and integrated analysis of genomic data for the mitochondrial disease clinical and research communities

Ribonucleotide discrimination and reverse transcription by the human mitochondrial DNA polymerase.

Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.

Clinical and molecular features of POLG-related mitochondrial disease.

Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine.

DNA polymerase gamma in mitochondrial DNA replication and repair

Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance

mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae

Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.

The mitochondrial DNA polymerase in health and disease.

Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome.

Progressive external ophthalmoplegia and vision and hearing loss in a patient with mutations in POLG2 and OPA1.

R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity

The interface of transcription and DNA replication in the mitochondria

Defects of mitochondrial DNA replication.