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List of works by Graham Packham

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B-cell receptor signaling in chronic lymphocytic leukemia.

scientific article published on 3 August 2011
Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

scientific article published on 26 September 2002
Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

scientific article
Mcl-1.

scientific article published in February 2005
Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

scientific article published on June 2004
Chronic lymphocytic leukaemia

article
MicroRNAs: key players in carcinogenesis and novel therapeutic targets.

scientific article published on 21 July 2008
miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance

scientific article published on 15 August 2013
Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

scientific article published on 15 May 2007
Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins

scientific article
Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia.

scientific article
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

scientific article published on 21 December 2015
Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression

scientific article
The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

scientific article
Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling.

scientific article published on 21 April 2008
S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition.

scientific article published on 17 June 2010
A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.

scientific article
BAG-1: a multifunctional regulator of cell growth and survival

scientific article
The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.

scientific article
Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells.

scientific article
The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription.

scientific article published in August 2003
The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.

scientific article published on 3 November 2009
FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role.

scientific article published on 04 July 2013
Targeting B-cell anergy in chronic lymphocytic leukemia.

scientific article published on 4 March 2013
The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy

scientific article
Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

scientific article published on 19 August 2008
Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.

scientific article
The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer.

scientific article published on 16 May 2014
Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

scientific article published on 13 February 2011
Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

scientific article published on 21 August 2006
BAG-1: a multi-functional pro-survival molecule

scientific article published on 01 February 2005
The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor

scientific article
Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.

scientific article published on 17 April 2009
The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumours

scientific article published on 01 February 2000
BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity

scientific article published on 19 January 2008
A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53

scientific article
BAG-1 expression and function in human cancer

scientific article
BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome.

scientific article published on 20 February 2004
Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function

scientific article
Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro

scientific article published on 01 March 2001
Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis

scientific article published on January 12, 2012
Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

scientific article published on 17 February 2011
Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.

scientific article published on 10 June 2016
Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells.

scientific article published on 20 July 2015
The desmoplastic reaction surrounding hepatic colorectal adenocarcinoma metastases aids tumor growth and survival via alphav integrin ligation.

scientific article published on October 2008
BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data.

scientific article
Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma

scientific article published on 17 March 2015
A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.

scientific article published on 18 October 2013
Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs

scientific article published on March 2015
Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo

scientific article published on 17 March 2010

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