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Authors whose works are in public domain in at least one jurisdiction

List of works by Matthew G Vander Heiden

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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article published on 23 January 2018
Metabolic targets for cancer therapy

scientific article published on October 11, 2013
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

scientific article
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

scientific article
PKM2, cancer metabolism, and the road ahead

scientific article published on 17 November 2016
Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

scientific article published on 15 August 2017
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article
Aspartate is an endogenous metabolic limitation for tumour growth

scientific article published on 25 June 2018
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

scientific article published on 2 October 2017
Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

scientific article published on 07 August 2018
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

scientific article published on 16 April 2019
Circulating Metabolites and Survival Among Patients With Pancreatic Cancer

scientific article published on 11 January 2016
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

scientific article published on 22 October 2018
Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation

scientific article published on 16 September 2019
Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

article
The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study

scientific article published on 07 December 2016
A framework for examining how diet impacts tumour metabolism

scientific article published on 17 September 2019
Gene expression profiling of prostate tissue identifies chromatin regulation as a potential link between obesity and lethal prostate cancer

scientific article published on 12 July 2017
Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate

scientific article published in Journal of Biological Chemistry
Erratum: Metabolic targets for cancer therapy

scholarly article published in Nature Reviews Drug Discovery
Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance

scientific article published on 04 September 2019
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

scientific article published on 06 December 2019
Identification of DHODH as a therapeutic target in small cell lung cancer

scientific article published on 01 November 2019
Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer

scientific article published on 26 January 2021
Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

scientific article published on 10 July 2020
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

scientific article published on 01 February 2020
A metastasis map of human cancer cell lines

scientific article published on 09 December 2020
Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division

scientific article published on 05 October 2020
Data from Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression

scientific article published on 30 October 2020
Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

scientific article published on 18 May 2022
Methionine synthase is essential for cancer cell proliferation in physiological folate environments

scientific article published on 18 November 2021
Supplementary Figure from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Supplementary Figures S1-S9, Supplementary Table S1 from Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Supplementary Figure from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Data from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

scientific article published in 2022
Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1

scientific article published on 08 June 2020
Supplementary Figure from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Transcriptional activation of macropinocytosis by the Hippo pathway following nutrient limitation

scientific article published on 01 October 2020
REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

scientific article published on 09 November 2020
Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity

scientific article published on 16 November 2019
Supplementary Figure from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer

scientific article published on 18 September 2019
Supplementary Figure from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Supplementary Table from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Supplementary Figure from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth

scientific article published in 2021

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