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List of works by Charles W Roberts

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Mutational heterogeneity in cancer and the search for new cancer-associated genes

scientific article
SWI/SNF nucleosome remodellers and cancer.

scientific article published on 09 June 2011
Targeting EZH2 in cancer

scientific article
The SWI/SNF complex--chromatin and cancer.

scientific article published on February 2004
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

scientific article
Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

scientific journal article
Toward understanding and exploiting tumor heterogeneity

scientific article
Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

scientific article (publication date: 5 July 1991)
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

scientific article published on 3 June 2016
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers

scientific article
ARID1A mutations in cancer: another epigenetic tumor suppressor?

scientific article
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5

scientific article published on 01 November 2002
Hox11 controls the genesis of the spleen

scientific article published in Nature
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

scientific article
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

scientific article
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

scientific article
ARID1B is a specific vulnerability in ARID1A-mutant cancers.

scientific article
Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.

scientific article
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

scientific article
On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice.

scientific article
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation

scientific article
Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.

scientific article published on 29 September 2009
Vulnerabilities of mutant SWI/SNF complexes in cancer.

scientific article published on September 2014
Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters

scientific article published on 30 May 2013
The role of SMARCB1/INI1 in development of rhabdoid tumor.

scientific article published on 29 March 2009
Linking the SWI/SNF complex to prostate cancer.

scientific article published in November 2013
Metagene projection for cross-platform, cross-species characterization of global transcriptional states

scholarly article
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

scientific article
SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

scientific article
The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors

scientific article published on January 1, 2002
Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study.

scientific article published on 28 January 2016
Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.

scientific article
AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection

scientific article published in December 2017
Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.

scientific article published on 11 October 2013
Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences

scientific article
Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies

scientific article published on 10 January 2016
The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

scientific article
TCR-dependent transformation of mature memory phenotype T cells in mice

scientific article
SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity

scientific article published on 20 May 2009
Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity

scientific article
Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth.

scientific article
Mutational processes shape the landscape of TP53 mutations in human cancer.

scientific article
Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.

scientific article published on 19 September 2012
Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5.

scientific article published on 25 February 2013
Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation.

scientific article
Epigenetics and cancer without genomic instability.

scientific article
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

scientific article published on 8 February 2017
PGBD5 promotes site-specific oncogenic mutations in human tumors

scientific article published on 15 May 2017
Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors

scientific article
The SWI/SNF tumor suppressor complex: Regulation of promoter nucleosomes and beyond

scientific article published on 30 September 2013

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