List of works - Aldons Jake Lusis

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

scientific article

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

scientific article

Mapping the genetic architecture of gene expression in human liver

scientific article

Variations in DNA elucidate molecular networks that cause disease

scientific article

Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics

scientific article

The Collaborative Cross, a community resource for the genetic analysis of complex traits

article

Tissue-specific expression and regulation of sexually dimorphic genes in mice

scientific article

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

scientific article

Integrative approaches for large-scale transcriptome-wide association studies

scientific article published on 8 February 2016

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

scientific article published on January 8, 2013

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

scientific article

Integrating genetic and network analysis to characterize genes related to mouse weight

scientific article published on 5 July 2006

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

scientific article published on March 15, 1990

Systems genetics approaches to understand complex traits

scientific article published on 03 December 2013

Comparative analysis of proteome and transcriptome variation in mouse

scientific article

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

scientific article published on 29 February 2004

A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species

scientific article published on 27 February 2002

The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL.

scientific article published on April 2004

Myeloperoxidase, a leukocyte-derived vascular NO oxidase

scientific article published in June 2002

The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture

scientific article published on July 1996

Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice

scientific article

Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress

scientific article published on 17 January 2008

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk

scientific article

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

scientific article published on June 23, 2011

Dosage compensation is less effective in birds than in mammals

scientific article

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis

scientific article (publication date: 2004)

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

scientific article

Human lipoprotein lipase complementary DNA sequence

scholarly article

Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids

scholarly article

The unfolded protein response is an important regulator of inflammatory genes in endothelial cells

scientific article

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

scientific article

A high-resolution association mapping panel for the dissection of complex traits in mice

scientific article

Cis-acting expression quantitative trait loci in mice

scientific article

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.

scientific article

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

scientific article published on December 30, 2014

Multi-omics approaches to disease

scientific article

Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice

scientific article

Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis

scientific article published on June 2000

Individual diet has sex-dependent effects on vertebrate gut microbiota

scientific article

Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

scientific article (publication date: November 2002)

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

scientific article published on 2 January 2008

Weighted gene coexpression network analysis strategies applied to mouse weight

scientific article

Metabolic syndrome: from epidemiology to systems biology

scientific article

Genetics of atherosclerosis

scientific article published in January 2004

Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.

scientific article

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice

scientific article

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

scientific journal article

γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

scientific article

Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids

scientific article (publication date: April 2001)

Increased atherosclerosis in myeloperoxidase-deficient mice

scientific article

List of works by Aldons Jake Lusis

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

Mapping the genetic architecture of gene expression in human liver

Variations in DNA elucidate molecular networks that cause disease

Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics

The Collaborative Cross, a community resource for the genetic analysis of complex traits

Tissue-specific expression and regulation of sexually dimorphic genes in mice

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

Integrative approaches for large-scale transcriptome-wide association studies

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Integrating genetic and network analysis to characterize genes related to mouse weight

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

Systems genetics approaches to understand complex traits

Comparative analysis of proteome and transcriptome variation in mouse

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species

The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL.

Myeloperoxidase, a leukocyte-derived vascular NO oxidase

The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture

Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice

Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

Dosage compensation is less effective in birds than in mammals

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

Human lipoprotein lipase complementary DNA sequence

Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids

The unfolded protein response is an important regulator of inflammatory genes in endothelial cells

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

A high-resolution association mapping panel for the dissection of complex traits in mice

Cis-acting expression quantitative trait loci in mice

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

Multi-omics approaches to disease

Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice

Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis

Individual diet has sex-dependent effects on vertebrate gut microbiota

Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

Weighted gene coexpression network analysis strategies applied to mouse weight

Metabolic syndrome: from epidemiology to systems biology

Genetics of atherosclerosis

Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids

Increased atherosclerosis in myeloperoxidase-deficient mice