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List of works by Charlotte Ling

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Epigenetic differences arise during the lifetime of monozygotic twins

scientific article
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

scientific article published in August 2007
Epigenetics: a molecular link between environmental factors and type 2 diabetes

scientific article
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue

scientific article
Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

scientific article
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

scientific article
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes

scientific article published on 8 May 2014
Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes

scientific article
Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

scientific article
Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

scientific article
Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

scientific article
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

scientific article published on 08 May 2014
Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle

scientific article (publication date: November 2007)
Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets

scientific article
Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

article published in 2015
Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

scientific article published on 6 March 2013
Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets

scientific article
Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

scientific article published on 08 September 2012
Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner

scientific article published on 21 April 2010
Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle

article
A central role for GRB10 in regulation of islet function in man.

scientific article published on 3 April 2014
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue

scientific article
Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets

scientific article
Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

scientific article
Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort

scientific article
Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue

scientific article published on 08 July 2009
A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

scientific article published on 25 February 2009
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

scientific article
Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue

scientific article published in April 2003
Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

scientific article published on 21 September 2009
Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

scientific article published on 23 August 2012
Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels

scientific article
Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets

scientific article
Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes

scientific article published on 07 July 2008
Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial.

scientific article
A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

scientific article published on January 2011
Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy

scientific article published on 6 August 2015
DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

scientific article published on 05 May 2016
Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes

scientific article published on 05 March 2009
Epigenetic adaptation to regular exercise in humans

scientific article published on March 14, 2014
DNA methylation in the pathogenesis of type 2 diabetes in humans

scientific article published on 7 February 2018
DNA Methylation as a Diagnostic and Therapeutic Target in the Battle Against Type 2 Diabetes

scientific article published on January 1, 2015
Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis

scientific article
Regulation of core clock genes in human islets

scientific article published on 2 February 2012
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits

scientific article
NIH working group report-using genomic information to guide weight management: From universal to precision treatment

scientific article
Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding

scientific article
DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

scientific article
Epigenetics and obesity: the devil is in the details

scientific article published on December 21, 2010
Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people

scientific article published on 13 July 2010

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