List of works - Karen L Mohlke

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

Discovery and refinement of loci associated with lipid levels

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scientific article

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

scientific article

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

scientific article (publication date: 11 August 2012)

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Common variants at 30 loci contribute to polygenic dyslipidemia

scientific article

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

A reference panel of 64,976 haplotypes for genotype imputation

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Variants in MTNR1B influence fasting glucose levels

scientific article

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

A map of open chromatin in human pancreatic islets

scientific article

Identification of ten loci associated with height highlights new biological pathways in human growth

scientific article

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

scientific article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways

scientific article

Genetic variants influencing circulating lipid levels and risk of coronary artery disease

scientific article published on 23 September 2010

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

scientific article

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

scientific article

FTO genotype is associated with phenotypic variability of body mass index

scientific article published on 16 September 2012

Common variants in the GDF5-UQCC region are associated with variation in human height

scientific article

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

scientific article

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

scientific article

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

scientific article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

scientific article

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

scientific article published on 2 December 2012

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

scientific article published in April 2004

List of works by Karen L Mohlke

Biological, clinical and population relevance of 95 loci for blood lipids

Genetic studies of body mass index yield new insights for obesity biology

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Discovery and refinement of loci associated with lipid levels

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Defining the role of common variation in the genomic and biological architecture of adult human height

Common variants at 30 loci contribute to polygenic dyslipidemia

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

A reference panel of 64,976 haplotypes for genotype imputation

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

New genetic loci link adipose and insulin biology to body fat distribution

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Variants in MTNR1B influence fasting glucose levels

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

The genetic architecture of type 2 diabetes

A map of open chromatin in human pancreatic islets

Identification of ten loci associated with height highlights new biological pathways in human growth

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

Common variants associated with plasma triglycerides and risk for coronary artery disease

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways

Genetic variants influencing circulating lipid levels and risk of coronary artery disease

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

FTO genotype is associated with phenotypic variability of body mass index

Common variants in the GDF5-UQCC region are associated with variation in human height

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

Rare and low-frequency coding variants alter human adult height

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes