List of works - Dan Roden

Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation

scientific article

Pharmacogenomics: challenges and opportunities

scientific article published on November 2006

Drug-induced long QT and torsade de pointes: recent advances

scientific article published on January 2007

Genetics of acquired long QT syndrome

scientific article

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation

scientific article published on 19 March 2013

Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes

scientific article

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

scientific article published on June 20, 2012

Close bidirectional relationship between chronic kidney disease and atrial fibrillation: the Niigata preventive medicine study

scientific article published in October 2009

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

scholarly article

Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)

scientific article

Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction.

scientific article published on 16 January 2006

Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation

scientific article published on 13 January 2009

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system

scientific journal article

A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes

scientific article published on 18 November 2011

Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population

scientific article

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

scientific article

PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability

scientific article

The phenotypic legacy of admixture between modern humans and Neandertals

scientific article

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects

scientific article published on 12 September 2013

Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality

scientific article

Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records

scientific article published on January 2016

Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records

scientific article

Biobanks and electronic medical records: enabling cost-effective research

scientific article

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

scientific article

Genome-wide association studies in pharmacogenomics: successes and lessons

scientific article

Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery

scientific article

Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction

scientific article

Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record

scientific article

Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.

scientific article

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia

scientific article published on 06 June 2012

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

scientific article published on February 2017

The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome

scientific article published on June 2008

Global implementation of genomic medicine: We are not alone

scientific article

eMERGEing progress in genomics-the first seven years

scientific article

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

scientific article

Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization

scientific article published on 03 August 2009

Multi-ethnic genome-wide association study for atrial fibrillation

article

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro

scientific article published on 8 August 2011

Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research

scientific article

Phenome-Wide Association Studies as a Tool to Advance Precision Medicine

scientific article

Pharmacogenomics: the genetics of variable drug responses

scientific article

Electronic health record design and implementation for pharmacogenomics: a local perspective

scientific article published on 05 September 2013

Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management

scientific article

Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin

scientific article published on July 2011

Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds

scientific article published on 9 November 2010

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

scientific article

Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study

scientific article published on 12 November 2018

Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia

scientific article

Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation

scientific article

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.

scientific article published on 17 February 2015

List of works by Dan Roden

Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation

Pharmacogenomics: challenges and opportunities

Drug-induced long QT and torsade de pointes: recent advances

Genetics of acquired long QT syndrome

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation

Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

Close bidirectional relationship between chronic kidney disease and atrial fibrillation: the Niigata preventive medicine study

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)

Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction.

Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system

A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes

Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability

The phenotypic legacy of admixture between modern humans and Neandertals

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects

Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality

Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records

Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records

Biobanks and electronic medical records: enabling cost-effective research

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Genome-wide association studies in pharmacogenomics: successes and lessons

Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery

Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction

Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record

Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome

Global implementation of genomic medicine: We are not alone

eMERGEing progress in genomics-the first seven years

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization

Multi-ethnic genome-wide association study for atrial fibrillation

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro

Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research

Phenome-Wide Association Studies as a Tool to Advance Precision Medicine

Pharmacogenomics: the genetics of variable drug responses

Electronic health record design and implementation for pharmacogenomics: a local perspective

Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management

Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin

Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study

Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia

Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.