List of works - James G Kench

International network of cancer genome projects

scientific article

Whole genomes redefine the mutational landscape of pancreatic cancer

scientific article published in February 2015

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

scientific article

Genomic analyses identify molecular subtypes of pancreatic cancer

scientific article published on 24 February 2016

Beyond insulin resistance in NASH: TNF-alpha or adiponectin?

scientific article published in July 2004

Visceral fat: a key mediator of steatohepatitis in metabolic liver disease.

scientific article

Whole-genome landscape of pancreatic neuroendocrine tumours.

scientific article published on 15 February 2017

Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C.

scientific article published in August 2003

Margin clearance and outcome in resected pancreatic cancer

scientific article

Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer.

scientific article published on July 2004

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

scientific article

Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse.

scientific article

Insulin resistance and response to therapy in patients infected with chronic hepatitis C virus genotypes 2 and 3.

scientific article published in October 2007

Stabilization of beta-catenin induces pancreas tumor formation

scientific article published on 09 July 2008

DPC4/Smad4 Expression and Outcome in Pancreatic Ductal Adenocarcinoma

article

Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma.

scientific article published on June 2002

Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia

scientific article

Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development

scientific article

Genotype-specific interactions of insulin resistance, steatosis, and fibrosis in chronic hepatitis C.

scientific article published in September 2008

The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome

scientific article

Grade of deceased donor liver macrovesicular steatosis impacts graft and recipient outcomes more than the Donor Risk Index.

scientific article published on March 2012

A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes.

scientific article published on 17 August 2009

Hypermutation In Pancreatic Cancer

scientific article

Zinc-alpha2-glycoprotein Expression as a Predictor of Metastatic Prostate Cancer Following Radical Prostatectomy

article

ERG induces taxane resistance in castration-resistant prostate cancer

scientific article

Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater

scientific article published on 25 February 2013

Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.

scientific article published in May 2004

Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia.

scientific article

Lower levels of nuclear beta-catenin predict for a poorer prognosis in localized prostate cancer.

scientific article

Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer.

scientific article

Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer

scientific article published on 16 April 2009

Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions.

scientific article published on 24 July 2006

High Gleason grade carcinoma at a positive surgical margin predicts biochemical failure after radical prostatectomy and may guide adjuvant radiotherapy.

scientific article published on 12 October 2011

Meta-analysis of radical resection rates and margin assessment in pancreatic cancer

scientific article published on 09 September 2015

Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro

scientific article

Synoptic reporting improves histopathological assessment of pancreatic resection specimens

scientific article

TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation.

scientific article published on 31 July 2009

Precursor lesions in pancreatic cancer: morphological and molecular pathology.

scientific article published on April 2011

Aberrant Neuropeptide Y and Macrophage Inhibitory Cytokine-1 Expression Are Early Events in Prostate Cancer Development and Are Associated with Poor Prognosis

article

Recruitment and activation of pancreatic stellate cells from the bone marrow in pancreatic cancer: a model of tumor-host interaction

scientific article

Ipilimumab-induced toxicities and the gastroenterologist.

scientific article

Classification, morphology and molecular pathology of premalignant lesions of the pancreas.

scientific article published on April 2013

High sensitivity C-reactive protein values do not reliably predict the severity of histological changes in NAFLD.

scientific article

Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27.

scientific article published on 5 September 2013

Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer.

scientific article

Pancreatic Intraepithelial Neoplasia in Association With Intraductal Papillary Mucinous Neoplasms of the Pancreas

article

Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer

scientific article

Clinical and pathologic features of familial pancreatic cancer

scientific article published on 14 October 2014

Patterns of DNA mutations and ALK rearrangement in resected node negative lung adenocarcinoma.

scientific article published on April 2013

Epigenetic deregulation across chromosome 2q14.2 differentiates normal from prostate cancer and provides a regional panel of novel DNA methylation cancer biomarkers.

scientific article

List of works by James G Kench

International network of cancer genome projects

Whole genomes redefine the mutational landscape of pancreatic cancer

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Genomic analyses identify molecular subtypes of pancreatic cancer

Beyond insulin resistance in NASH: TNF-alpha or adiponectin?

Visceral fat: a key mediator of steatohepatitis in metabolic liver disease.

Whole-genome landscape of pancreatic neuroendocrine tumours.

Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C.

Margin clearance and outcome in resected pancreatic cancer

Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer.

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse.

Insulin resistance and response to therapy in patients infected with chronic hepatitis C virus genotypes 2 and 3.

Stabilization of beta-catenin induces pancreas tumor formation

DPC4/Smad4 Expression and Outcome in Pancreatic Ductal Adenocarcinoma

Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma.

Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia

Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development

Genotype-specific interactions of insulin resistance, steatosis, and fibrosis in chronic hepatitis C.

The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome

Grade of deceased donor liver macrovesicular steatosis impacts graft and recipient outcomes more than the Donor Risk Index.

A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes.

Hypermutation In Pancreatic Cancer

Zinc-alpha2-glycoprotein Expression as a Predictor of Metastatic Prostate Cancer Following Radical Prostatectomy

ERG induces taxane resistance in castration-resistant prostate cancer

Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater

Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.

Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia.

Lower levels of nuclear beta-catenin predict for a poorer prognosis in localized prostate cancer.

Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer.

Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer

Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions.

High Gleason grade carcinoma at a positive surgical margin predicts biochemical failure after radical prostatectomy and may guide adjuvant radiotherapy.

Meta-analysis of radical resection rates and margin assessment in pancreatic cancer

Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro

Synoptic reporting improves histopathological assessment of pancreatic resection specimens

TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation.

Precursor lesions in pancreatic cancer: morphological and molecular pathology.

Aberrant Neuropeptide Y and Macrophage Inhibitory Cytokine-1 Expression Are Early Events in Prostate Cancer Development and Are Associated with Poor Prognosis

Recruitment and activation of pancreatic stellate cells from the bone marrow in pancreatic cancer: a model of tumor-host interaction

Ipilimumab-induced toxicities and the gastroenterologist.

Classification, morphology and molecular pathology of premalignant lesions of the pancreas.

High sensitivity C-reactive protein values do not reliably predict the severity of histological changes in NAFLD.

Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27.

Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer.

Pancreatic Intraepithelial Neoplasia in Association With Intraductal Papillary Mucinous Neoplasms of the Pancreas

Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer

Clinical and pathologic features of familial pancreatic cancer

Patterns of DNA mutations and ALK rearrangement in resected node negative lung adenocarcinoma.

Epigenetic deregulation across chromosome 2q14.2 differentiates normal from prostate cancer and provides a regional panel of novel DNA methylation cancer biomarkers.