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List of works by Oriol Casanovas

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

scientific article
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

scientific article (publication date: October 2005)
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

scientific journal article
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing

scientific article
Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner

scientific article published on November 2000
Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

scientific article published on 9 April 2012
The Protein SET Regulates the Inhibitory Effect of p21Cip1on Cyclin E-Cyclin-dependent Kinase 2 Activity

scientific article published in Journal of Biological Chemistry
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

scientific article published on 11 February 2013
Antiangiogenic therapies: going beyond their limits

scientific article published on 19 December 2013
Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients.

scientific article
Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2.

scientific article
PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

scientific article
Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization

scientific article published on 5 May 2011
Pazopanib in pretreated advanced neuroendocrine tumors: a phase II, open-label trial of the Spanish Task Force Group for Neuroendocrine Tumors (GETNE).

scientific article published on 10 June 2015
Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action.

scientific article published on 15 November 2016
Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model

scientific article
Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors.

scientific article published on 5 May 2009
Molecular pathogenesis of neuroendocrine tumors: implications for current and future therapeutic approaches

scientific article published on 04 March 2013
The PDGFRβ-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors

scientific article published on 25 November 2013
Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis

scientific article
Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells

scientific article published on 4 June 2013
Anti‐angiogenesis and metastasis: a tumour and stromal cell alliance

scientific article published on February 1, 2013
Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

scientific article published on 16 September 2013
P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation

scientific article published on September 2004
Use of a mouse model of pancreatic neuroendocrine tumors to find pericyte biomarkers of resistance to anti-angiogenic therapy

scientific article published on 29 September 2011
Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis

scientific article published in October 2005
Unraveling the Role of Angiogenesis in Cancer Ecosystems.

scientific article published on 2 July 2018
The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels.

scientific article published on 14 June 2016
The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers

scientific journal article
Limitations of therapies exposed

scientific article published on April 4, 2012
Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors

scientific article
Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors

scientific article
The Cell Cycle Inhibitor p21CIPIs Phosphorylated by Cyclin A-CDK2 Complexes

scientific article published on 01 December 1997
Molecular biology of neuroendocrine tumors: from pathways to biomarkers and targets

scientific article published on March 2014
New drug development in digestive neuroendocrine tumors

scientific article published on 13 February 2007
Translational research in neuroendocrine tumors: pitfalls and opportunities

scientific article published on 19 September 2016
Angiogenesis and Metabolism: Entwined for Therapy Resistance

scientific article
MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes

scientific article published on 25 January 2016
ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor.

scientific article
Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

scientific article
The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients

scientific article published on 05 August 2016
Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype

scientific article published on 05 February 2014
The adaptive stroma joining the antiangiogenic resistance front

scientific article published on March 23, 2011
Antiangiogenic Resistance: Novel Angiogenesis Axes Uncovered by Antiangiogenic Therapies Research

scientific article published on 01 January 2016
Relevance of angiogenesis in neuroendocrine tumors

scientific article published on 17 May 2012
Scanning, non-contact, hybrid broadband diffuse optical spectroscopy and diffuse correlation spectroscopy system

scientific article published on 15 January 2016
Exploiting pleiotropic activities of semaphorins as multi‐target therapies for cancer

scientific article published on February 10, 2012
The use of caspase inhibitors in pulsed-field gel electrophoresis may improve the estimation of radiation-induced DNA repair and apoptosis.

scientific article published on 15 January 2011
Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis

scientific article
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

scientific article published in Nature Communications

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