List of works - María L López-Rodríguez

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

scientific article (publication date: 3 October 2003)

Mitochondrial CB₁ receptors regulate neuronal energy metabolism

scientific article published on 4 March 2012

Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells

scientific article published on March 2007

A cannabinoid link between mitochondria and memory.

scientific article published on 9 November 2016

The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.

scientific article published on 8 March 2010

Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis--a difficult issue to handle

scientific article

The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors

scientific article published on January 2007

Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis

scientific article published on 7 June 2005

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

scientific article published on 01 December 2009

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.

scientific article published on 16 December 2011

New synthetic inhibitors of fatty acid synthase with anticancer activity

scientific article published on 16 May 2012

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

scientific article (publication date: 11 September 2014)

Arylpiperazine derivatives acting at 5-HT(1A) receptors.

scientific article

UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.

scientific article published on 11 July 2005

Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.

scientific article

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

scientific article published on 08 October 2014

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

scientific article published on 3 November 2014

Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.

scientific article

Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study.

scientific article published on 12 January 2004

Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

scientific article

Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity

scientific article published on January 2007

UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide

scientific article published in August 2002

Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.

scientific article published in October 1996

Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity

scientific article

2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination.

scientific article

Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors

scientific article published in April 2003

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

scientific article published in June 2005

Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer.

scientific article published on October 2010

Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed [...]

scientific article

Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives

scientific article

2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs.

scientific article published on 27 February 2018

Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action

scientific article published on 30 December 2014

Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparis

scientific article published on 01 May 1997

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

scientific article published on 10 January 2017

Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors

scientific article published on 01 December 1999

New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.

scientific article published on 8 October 2013

Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites

scientific article published on 01 November 1997

Synthesis and structure-activity relationships of a new model of arylpiperazines. 3.1 2-[omega-(4-arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: study of the influence of the terminal amide fragment

scientific article published in August 1997

Ligand chain length drives activation of lipid G protein-coupled receptors

scientific article published on 17 May 2017

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

scientific article

New inhibitors of angiogenesis with antitumor activity in vivo

scientific article published on 4 May 2015

Chemical probes for the recognition of cannabinoid receptors in native systems

scientific article

Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin

scientific article published in June 2003

Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists

scientific article published in October 2002

A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.

scientific article published on 24 January 2017

Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.

scientific article

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

scientific article published on 11 November 2011

Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors

scientific article

Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.

scientific article published in July 2002

Monoacylglycerol lipase (MAGL) as a promising therapeutic target

scientific article published on 27 July 2018

List of works by María L López-Rodríguez

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

Mitochondrial CB₁ receptors regulate neuronal energy metabolism

Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells

A cannabinoid link between mitochondria and memory.

The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.

Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis--a difficult issue to handle

The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors

Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.

New synthetic inhibitors of fatty acid synthase with anticancer activity

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

Arylpiperazine derivatives acting at 5-HT(1A) receptors.

UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.

Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.

Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study.

Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity

UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide

Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.

Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity

2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination.

Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer.

Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed [...]

Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives

2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs.

Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action

Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparis

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors

New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.

Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites

Synthesis and structure-activity relationships of a new model of arylpiperazines. 3.1 2-[omega-(4-arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: study of the influence of the terminal amide fragment

Ligand chain length drives activation of lipid G protein-coupled receptors

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

New inhibitors of angiogenesis with antitumor activity in vivo

Chemical probes for the recognition of cannabinoid receptors in native systems

Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin

Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists

A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.

Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors

Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.

Monoacylglycerol lipase (MAGL) as a promising therapeutic target