List of works - John A Beutler

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

scientific article

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

scientific article

Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

scientific article published on January 2009

A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1

scientific article (publication date: 29 May 1992)

Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp

scientific article published on November 14, 1997

The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices

scientific article published on 01 September 1991

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

scientific article

Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600

scientific article

Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality

scientific article

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

scientific article

A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H

scientific article published on 31 March 2007

Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae

scientific article published on 01 January 2001

Structure-activity requirements for flavone cytotoxicity and binding to tubulin.

scientific article published on June 1998

Novel cytotoxic diterpenes from Casearia arborea.

scientific article published in May 2000

1H- and 13C-nmr assignments for taxol, 7-epi-taxol, and cephalomannine

scientific article published on 01 April 1992

Securinine alkaloids: a new class of GABA receptor antagonist.

scientific article published in March 1985

A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts

scientific article published on 01 July 1993

New dimeric macrolide glycosides from the marine sponge Myriastra clavosa.

scientific article published in September 2002

Synthesis of nonracemic 3-deoxyschweinfurthin B.

scientific article published on February 2005

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.

scientific article published on 12 December 2006

Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth

scientific article

Novel marine and microbial natural product inhibitors of vacuolar ATPase.

scientific article

Majapolene A, a cytotoxic peroxide, and related sesquiterpenes from the red alga Laurencia majuscula.

scientific article published on December 1995

Peptide HIV-1 integrase inhibitors from HIV-1 gene products.

scientific article

Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.

scientific article published on 4 May 2010

Cytotoxic clerodane diterpene esters from Laetia corymbulosa

scientific article published on 01 October 2000

Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor

scientific article

Exploiting Drug-Resistant Enzymes as Tools To Identify Thienopyrimidinone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

scientific article published on June 20, 2013

Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species.

scientific article

Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity.

scientific article published on 14 November 2005

Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula

scientific article

New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H.

scientific article

Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure

scientific article

Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones

scientific article published on February 18, 2011

Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.

scientific article

Anti-HIV and Cytotoxic Alkaloids from Buchenavia capitata

scientific article (publication date: February 1992)

Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors

scientific article published on February 2016

Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.

scientific article

Identification of CB1/CB2 Ligands from Zanthoxylum bungeanum

scientific article published on October 31, 2013

Chlorinated englerins with selective inhibition of renal cancer cell growth

scientific article published on 26 January 2012

Dereplication of phorbol bioactives: Lyngbya majuscula and Croton cuneatus

scientific article published on 01 July 1990

Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2.

scientific article published on October 2006

Schweinfurthins I and J from Macaranga schweinfurthii.

scientific article

Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells.

scientific article

Englerins: A Comprehensive Review.

scientific article published on 7 February 2017

Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum.

scientific article

Synthesis and biological assessment of 3,7-dihydroxytropolones.

scientific article published on 3 November 2017

Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers

scientific article

Enantioselective Total Synthesis and Biological Evaluation of (+)-Kibdelone A and a Tetrahydroxanthone Analogue

scientific article published on July 23, 2013

Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties

scientific article

List of works by John A Beutler

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1

Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp

The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600

Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H

Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae

Structure-activity requirements for flavone cytotoxicity and binding to tubulin.

Novel cytotoxic diterpenes from Casearia arborea.

1H- and 13C-nmr assignments for taxol, 7-epi-taxol, and cephalomannine

Securinine alkaloids: a new class of GABA receptor antagonist.

A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts

New dimeric macrolide glycosides from the marine sponge Myriastra clavosa.

Synthesis of nonracemic 3-deoxyschweinfurthin B.

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.

Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth

Novel marine and microbial natural product inhibitors of vacuolar ATPase.

Majapolene A, a cytotoxic peroxide, and related sesquiterpenes from the red alga Laurencia majuscula.

Peptide HIV-1 integrase inhibitors from HIV-1 gene products.

Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.

Cytotoxic clerodane diterpene esters from Laetia corymbulosa

Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor

Exploiting Drug-Resistant Enzymes as Tools To Identify Thienopyrimidinone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species.

Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity.

Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula

New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H.

Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure

Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones

Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.

Anti-HIV and Cytotoxic Alkaloids from Buchenavia capitata

Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors

Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.

Identification of CB1/CB2 Ligands from Zanthoxylum bungeanum

Chlorinated englerins with selective inhibition of renal cancer cell growth

Dereplication of phorbol bioactives: Lyngbya majuscula and Croton cuneatus

Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2.

Schweinfurthins I and J from Macaranga schweinfurthii.

Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells.

Englerins: A Comprehensive Review.

Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum.

Synthesis and biological assessment of 3,7-dihydroxytropolones.

Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers

Enantioselective Total Synthesis and Biological Evaluation of (+)-Kibdelone A and a Tetrahydroxanthone Analogue

Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties