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List of works by Mikael Altun

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A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

scientific article
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

scientific article
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

scientific article
Structural basis and specificity of human otubain 1-mediated deubiquitination

scientific article
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway

scientific article
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

scientific article published in September 2001
Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.

scientific article
Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells

scientific article published on September 2005
Factors contributing to neuromuscular impairment and sarcopenia during aging.

scientific article published on 21 May 2007
Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes

scientific article
Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion

scientific article
Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia

scientific article published on November 29, 2011
Iron load and redox stress in skeletal muscle of aged rats

scientific article published on 01 August 2007
A photoreactive small-molecule probe for 2-oxoglutarate oxygenases

scientific article
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

scientific article published on 30 December 2015
Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development

scientific article
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

scientific article
Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection

scientific article published on 20 September 2011
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

scientific article published on 5 March 2018
The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages

scientific article published on 15 January 2015
Fluorescence-based active site probes for profiling deubiquitinating enzymes

scientific article published on 28 March 2012
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia

scientific article published on 5 December 2016
Photoactivable peptides for identifying enzyme–substrate and protein–protein interactions

scientific article published on 13 December 2010
Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment

scientific journal article
Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells

scientific article published on 11 December 2017
The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition

scientific article published in December 2017
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics

scientific article published on 12 February 2020
The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia

scientific article published on 29 March 2018
Muscle atrophy and regeneration associated with behavioural loss and recovery of function after sciatic nerve crush

scientific article published on 02 July 2019
Development of a chemical probe against NUDT15

scientific article published on 20 July 2020
Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound

scientific article published on 06 October 2021
The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation

scientific article published on 25 July 2018
Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts

scientific article published on 29 July 2019

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