List of works - Richard Southworth

Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation

Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis

scientific article published on 28 April 2011

Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart

scientific article published on April 2014

Renal vascular inflammation induced by Western diet in ApoE-null mice quantified by (19)F NMR of VCAM-1 targeted nanobeacons.

scientific article published on 19 January 2009

A reevaluation of the roles of hexokinase I and II in the heart.

scientific article

Monitoring of in vivo function of superparamagnetic iron oxide labelled murine dendritic cells during anti-tumour vaccination.

scientific article

PET imaging of cardiac hypoxia: opportunities and challenges.

scientific article published on 14 July 2011

Cardiac hypoxia imaging: second-generation analogues of 64Cu-ATSM.

scientific article published on 13 January 2014

Pathophysiological Consequences of TAT-HKII Peptide Administration Are Independent of Impaired Vascular Function and Ensuing Ischemia

scientific article published on January 18, 2013

Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidyl-inositol-3-kinase pathway in the rat heart.

scientific article

64Cu-CTS: A Promising Radiopharmaceutical for the Identification of Low-Grade Cardiac Hypoxia by PET.

scientific article published on 16 April 2015

Trapped platelets activated in ischemia initiate ventricular fibrillation

scientific article published on 31 August 2013

Dissociation of glucose tracer uptake and glucose transporter distribution in the regionally ischaemic isolated rat heart: application of a new autoradiographic technique.

scientific article published on 8 August 2002

Multiple quantum filtered (23)Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i

scientific article published on 18 July 2015

Demonstration of the retention of 64Cu-ATSM in cardiac myocytes using a novel incubation chamber for screening hypoxia-dependent radiotracers.

scientific article

Differential uptake of FDG and DG during post-ischaemic reperfusion in the isolated, perfused rat heart

scientific article published on 01 October 1999

Developmental Differences in Superoxide Production in Isolated Guinea-Pig Hearts During Reperfusion

scientific article published on July 1, 1998

Assessing radiotracer kinetics in the Langendorff perfused heart.

scientific article

Modeling non-linear kinetics of hyperpolarized [1-(13)C] pyruvate in the crystalloid-perfused rat heart.

scientific article published on 18 January 2016

Modification of intracellular glutathione status does not change the cardiac trapping of (64)Cu(ATSM)

scientific article published on August 2014

Opportunities and Challenges for Metal Chemistry in Molecular Imaging

scientific article published on 16 November 2015

Kinetic analysis of hyperpolarized data with minimum a priori knowledge: Hybrid maximum entropy and nonlinear least squares method (MEM/NLS).

scientific article

PET Imaging of Cardiac Hypoxia: Hitting Hypoxia Where It Hurts.

scientific article published on 23 February 2018

Tissue acidosis does not mediate the hypoxia selectivity of [Cu][Cu(ATSM)] in the isolated perfused rat heart

scientific article published in Scientific Reports

Imaging of Chemotherapy-Induced Acute Cardiotoxicity with 18F-Labeled Lipophilic Cations

scientific article published on 30 May 2019

Detection of anthracycline-induced cardiotoxicity using perfusion-corrected Tc sestamibi SPECT

scientific article published in Scientific Reports

DO2A-based ligands for gallium-68 chelation: synthesis, radiochemistry and ex vivo cardiac uptake

scientific article published on 24 December 2019

Synthesis, gallium-68 radiolabelling and biological evaluation of a series of triarylphosphonium-functionalized DO3A chelators

scientific article published on 17 October 2018

List of works by Richard Southworth

Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation

Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis

Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart

Renal vascular inflammation induced by Western diet in ApoE-null mice quantified by (19)F NMR of VCAM-1 targeted nanobeacons.

A reevaluation of the roles of hexokinase I and II in the heart.

Monitoring of in vivo function of superparamagnetic iron oxide labelled murine dendritic cells during anti-tumour vaccination.

PET imaging of cardiac hypoxia: opportunities and challenges.

Cardiac hypoxia imaging: second-generation analogues of 64Cu-ATSM.

Pathophysiological Consequences of TAT-HKII Peptide Administration Are Independent of Impaired Vascular Function and Ensuing Ischemia

Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidyl-inositol-3-kinase pathway in the rat heart.

64Cu-CTS: A Promising Radiopharmaceutical for the Identification of Low-Grade Cardiac Hypoxia by PET.

Trapped platelets activated in ischemia initiate ventricular fibrillation

Dissociation of glucose tracer uptake and glucose transporter distribution in the regionally ischaemic isolated rat heart: application of a new autoradiographic technique.

Multiple quantum filtered (23)Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i

Demonstration of the retention of 64Cu-ATSM in cardiac myocytes using a novel incubation chamber for screening hypoxia-dependent radiotracers.

Differential uptake of FDG and DG during post-ischaemic reperfusion in the isolated, perfused rat heart

Developmental Differences in Superoxide Production in Isolated Guinea-Pig Hearts During Reperfusion

Assessing radiotracer kinetics in the Langendorff perfused heart.

Modeling non-linear kinetics of hyperpolarized [1-(13)C] pyruvate in the crystalloid-perfused rat heart.

Modification of intracellular glutathione status does not change the cardiac trapping of (64)Cu(ATSM)

Opportunities and Challenges for Metal Chemistry in Molecular Imaging

Kinetic analysis of hyperpolarized data with minimum a priori knowledge: Hybrid maximum entropy and nonlinear least squares method (MEM/NLS).

PET Imaging of Cardiac Hypoxia: Hitting Hypoxia Where It Hurts.

Tissue acidosis does not mediate the hypoxia selectivity of [Cu][Cu(ATSM)] in the isolated perfused rat heart

Imaging of Chemotherapy-Induced Acute Cardiotoxicity with 18F-Labeled Lipophilic Cations

Detection of anthracycline-induced cardiotoxicity using perfusion-corrected Tc sestamibi SPECT

DO2A-based ligands for gallium-68 chelation: synthesis, radiochemistry and ex vivo cardiac uptake

Synthesis, gallium-68 radiolabelling and biological evaluation of a series of triarylphosphonium-functionalized DO3A chelators

Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart