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List of works by Jan­ne Back­man

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Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

scientific article
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

scientific article
Subtropical Arctic Ocean temperatures during the Palaeocene/Eocene thermal maximum

scientific article (publication date: June 2006)
Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers

scientific article published on 26 March 2009
Cyclosporine markedly raises the plasma concentrations of repaglinide

scientific article
Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites

scientific article
Frequencies of single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide 1B1 SLCO1B1 gene in a Finnish population

article
Episodic fresh surface waters in the Eocene Arctic Ocean

scientific article (publication date: June 2006)
Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions

scientific article published on 27 June 2014
The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects

scientific article published in April 2004
Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications

scientific article published on 02 April 2012
Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.

scientific article published on 28 March 2007
Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide

article published in 2006
Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses

scientific article published on 21 July 2011
Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

scientific article published on January 1, 2016
Effect of rifampicin on the pharmacokinetics of pioglitazone

scientific article published in January 2006
Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans

scientific article
Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone

scientific article published in September 2004
Telithromycin, but not montelukast, increases the plasma concentrations and effects of the cytochrome P450 3A4 and 2C8 substrate repaglinide

scientific article published on 7 February 2006
Itraconazole, a P-Glycoprotein and CYP3A4 Inhibitor, Markedly Raises the Plasma Concentrations and Enhances the Renin-Inhibiting Effect of Aliskiren

scholarly article by Tuija Tapaninen et al published March 2011 in The Journal of Clinical Pharmacology
VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection

scientific article published on 31 October 2016
Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine

scientific article published on 27 April 2006
CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe

scientific article published on 22 September 2009
Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans

scientific article published on 02 March 2011
Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects

scientific article published in September 2006
No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin

scientific article published on August 2009
Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses

scientific article published on 01 May 2012
Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response

scientific article published in October 2012
Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients

scientific article (publication date: February 2006)
Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates.

scientific article published on April 2012
In Vitro Assessment of Time-Dependent Inhibitory Effects on CYP2C8 and CYP3A Activity by Fourteen Protein Kinase Inhibitors

scientific article published on April 8, 2014
Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects

scientific article published in April 2005
Reevaluation of the Microsomal Metabolism of Montelukast: Major Contribution by CYP2C8 at Clinically Relevant Concentrations

scientific article published on 02 February 2011
Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial

scientific article published in January 2014
Long-term changes in cyclosporine pharmacokinetics after renal transplantation in children: evidence for saturable presystemic metabolism and effect of NR1I2 polymorphism

scientific article published on 27 January 2010
SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren

scientific article published in January 2013
An early Eocene carbon cycle perturbation at ∼52.5 Ma in the Southern Alps: Chronology and biotic response

article
Developmental pharmacokinetics of ciclosporin--a population pharmacokinetic study in paediatric renal transplant candidates.

scientific article published on 27 July 2007
In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions

scientific article published in August 2008
Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone

scientific article
Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide

scientific article published in August 2005
Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle.

scientific article published on 11 December 2017
SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

scientific article
Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide

scientific article published on 31 January 2006
Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing

scientific article published on March 2015
Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone

Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity

scientific article published on 7 October 2014
Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

scientific article published on June 2013
Effect of fluconazole on the pharmacokinetics and pharmacodynamics of nateglinide

scientific article published in July 2003

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