List of works - Lin Zhang

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Whole genome amplification from a single cell: implications for genetic analysis

scientific article published on July 1, 1992

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

scientific article

PUMA, a potent killer with or without p53

scientific article

A homochiral porous metal-organic framework for highly enantioselective heterogeneous asymmetric catalysis

scientific article

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

scientific article

PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis

scientific article

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

scientific article

p53/HMGB1 complexes regulate autophagy and apoptosis.

scientific article published on 16 February 2012

Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.

scientific article published on 20 February 2006

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.

scientific article

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

scientific article published in August 2017

p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion

scientific article

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.

scientific article

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress

scientific journal article

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.

scientific article

Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

scientific article

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.

scientific article published on 11 July 2016

Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.

scientific article

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

scientific article published on 22 September 2015

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis

scientific article published on November 16, 2010

SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events

scientific article

Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.

scientific article

PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.

scientific article

PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells

scientific article

Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia

scientific article published on 24 October 2016

Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells

scientific article published on 15 February 2017

Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth

scientific article published on 30 January 2012

A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells

scientific article published on 01 March 2007

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.

scientific article

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

scientific article

PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.

scientific article

Necroptosis: an alternative cell death program defending against cancer.

scientific article published on 8 March 2016

ADAR1 is essential for intestinal homeostasis and stem cell maintenance.

scientific article published on 18 April 2013

Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.

scientific article

Development of Small-Molecule PUMA Inhibitors for Mitigating Radiation-Induced Cell Death

scientific article published on January 1, 2011

Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms (review).

scientific article published on 22 May 2014

Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death

scientific article published on 31 January 2014

FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors

scientific article published on 15 June 2017

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice

scientific article

Autophagy Mediates HBx-Induced Nuclear Factor-κB Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes

scientific article

The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.

scientific article

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

scientific article

BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells

scientific article published on 24 June 2016

Role of apoptosis in colon cancer biology, therapy, and prevention

scientific article published on December 2013

Autophagy in sepsis: Degradation into exhaustion?

scientific article published on 12 May 2016

5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers

scientific article published on 18 October 2016

Immunogenic effects of chemotherapy-induced tumor cell death

scientific article published on 17 May 2018

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.

scientific article published on 8 February 2013

Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.

scientific article published on 21 August 2013

List of works by Lin Zhang

Guidelines for the use and interpretation of assays for monitoring autophagy

Whole genome amplification from a single cell: implications for genetic analysis

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

PUMA, a potent killer with or without p53

A homochiral porous metal-organic framework for highly enantioselective heterogeneous asymmetric catalysis

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

p53/HMGB1 complexes regulate autophagy and apoptosis.

Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.

Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.

Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis

SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events

Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.

PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.

PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells

Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia

Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells

Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth

A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.

Necroptosis: an alternative cell death program defending against cancer.

ADAR1 is essential for intestinal homeostasis and stem cell maintenance.

Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.

Development of Small-Molecule PUMA Inhibitors for Mitigating Radiation-Induced Cell Death

Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms (review).

Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death

FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice

Autophagy Mediates HBx-Induced Nuclear Factor-κB Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes

The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells

Role of apoptosis in colon cancer biology, therapy, and prevention

Autophagy in sepsis: Degradation into exhaustion?

5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers

Immunogenic effects of chemotherapy-induced tumor cell death

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.

Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.