List of works - Ann-Christine Syvänen

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Transcriptome and genome sequencing uncovers functional variation in humans

scientific article

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

scientific article

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Genome-wide association study identifies eight loci associated with blood pressure

scientific article (publication date: June 2009)

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

scientific article

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Genome sequence, comparative analysis, and population genetics of the domestic horse

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus

scholarly article

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

scientific article

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

scientific article

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

scientific article published on 26 June 2011

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

scientific article

A system for specific, high-throughput genotyping by allele-specific primer extension on microarrays

scientific article

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

Toward genome-wide SNP genotyping

scientific article

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

scientific article published on October 27, 2011

Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs

scientific article

Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories

scientific article published on 15 September 2013

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

scientific article

Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays.

scientific article

Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23

scientific article

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Sex chromosome evolution and speciation in Ficedula flycatchers

scientific article published in January 2003

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

scientific article published on 25 June 2008

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

article by Snaevar Sigurdsson et al published 6 December 2007 in Human Molecular Genetics

Investigation of the fine structure of European populations with applications to disease association studies

scientific article published in December 2008

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development

scientific article published on 17 February 2011

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis

article

A central role for GRB10 in regulation of islet function in man.

scientific article published on 3 April 2014

An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases

article

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia

scientific article

Genetic determinants of dabigatran plasma levels and their relation to bleeding

scientific article

Quantitative evaluation by minisequencing and microarrays reveals accurate multiplexed SNP genotyping of whole genome amplified DNA.

scientific article published on November 2003

Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease

scientific article

Geographical structure and differential natural selection among North European populations

scientific article published on 05 March 2009

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

scientific article

List of works by Ann-Christine Syvänen

Genetic studies of body mass index yield new insights for obesity biology

Transcriptome and genome sequencing uncovers functional variation in humans

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Defining the role of common variation in the genomic and biological architecture of adult human height

Large-scale association analysis identifies new risk loci for coronary artery disease

Genome-wide association study identifies eight loci associated with blood pressure

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

New genetic loci link adipose and insulin biology to body fat distribution

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Genome sequence, comparative analysis, and population genetics of the domestic horse

The genetic architecture of type 2 diabetes

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

A system for specific, high-throughput genotyping by allele-specific primer extension on microarrays

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Toward genome-wide SNP genotyping

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs

Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays.

Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Sex chromosome evolution and speciation in Ficedula flycatchers

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

Investigation of the fine structure of European populations with applications to disease association studies

A genome-wide association search for type 2 diabetes genes in African Americans

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis

A central role for GRB10 in regulation of islet function in man.

An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia

Genetic determinants of dabigatran plasma levels and their relation to bleeding

Quantitative evaluation by minisequencing and microarrays reveals accurate multiplexed SNP genotyping of whole genome amplified DNA.

Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease

Geographical structure and differential natural selection among North European populations

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus