List of works - Huaibin Cai

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

scientific article

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

scientific article

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

scientific article

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

scientific article

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

scientific article

Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans

scientific article published in June 2007

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

scientific article published in March 2008

Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.

scientific article

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

scientific article

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

scientific article

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

scientific article published on 2 November 2012

Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1

scientific article

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

scientific article

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

scientific article

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

scientific journal article

Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity

scientific article published on 17 January 2013

The G59S mutation in p150(glued) causes dysfunction of dynactin in mice

scientific article published on December 2007

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

scientific article

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

scientific article

Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.

scientific article

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

scientific article

Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina

scientific article published on 12 April 2007

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.

scientific article

LRRK2 function on actin and microtubule dynamics in Parkinson disease

scientific article

Autophagy in neurodegenerative diseases: pathogenesis and therapy.

scientific article

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus

scientific article

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.

scientific article

Nurr1-Based Therapies for Parkinson's Disease.

scientific article published on 25 March 2016

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

scientific article

α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.

scientific article published on April 2016

α-synuclein, LRRK2 and their interplay in Parkinson's disease.

scientific article

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson's disease

scientific article published on 2 March 2015

In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.

scientific article

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

scientific article

Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.

scientific article published on 3 February 2017

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.

scientific article published on 28 February 2017

Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.

scientific article

LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways

scientific article

ALS2/alsin knockout mice and motor neuron diseases

scientific article published on 20 August 2008

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice

scientific article published on November 14, 2012

Alsin and the molecular pathways of amyotrophic lateral sclerosis

scientific article published on 10 July 2007

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.

scientific article published on 28 August 2015

Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.

scientific article published in July 2015

Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response

scientific article published on 11 June 2015

Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.

scientific article

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease

scientific article

Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons

scientific article

Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress

scientific article

Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice

scientific article

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

scientific article

List of works by Huaibin Cai

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity

The G59S mutation in p150(glued) causes dysfunction of dynactin in mice

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.

LRRK2 function on actin and microtubule dynamics in Parkinson disease

Autophagy in neurodegenerative diseases: pathogenesis and therapy.

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.

Nurr1-Based Therapies for Parkinson's Disease.

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.

α-synuclein, LRRK2 and their interplay in Parkinson's disease.

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson's disease

In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.

Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.

LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways

ALS2/alsin knockout mice and motor neuron diseases

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice

Alsin and the molecular pathways of amyotrophic lateral sclerosis

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.

Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.

Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response

Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease

Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons

Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress

Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum