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List of works by Bissan Al-Lazikani

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How many drug targets are there?

scientific article
ChEMBL: a large-scale bioactivity database for drug discovery

scientific article (publication date: 2012)
The genome of the blood fluke Schistosoma mansoni

scientific article
Combinatorial drug therapy for cancer in the post-genomic era.

scientific article
Standard conformations for the canonical structures of immunoglobulins

scientific article
Defective acute inflammation in Crohn's disease: a clinical investigation

scientific article
Genomic-scale prioritization of drug targets: the TDR Targets database

scientific article
Therapeutic opportunities within the DNA damage response

scientific article
Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance

scientific article
Objective assessment of cancer genes for drug discovery

article
Minimum information about a bioactive entity (MIABE).

scientific article
JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.

scientific article
canSAR: updated cancer research and drug discovery knowledgebase

scientific article published on 03 December 2013
Effective function annotation through catalytic residue conservation

scientific article
Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation.

scientific article published on 19 August 2010
A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma

scientific article published on June 2011
canSAR: an integrated cancer public translational research and drug discovery resource

scientific article
canSAR: an updated cancer research and drug discovery knowledgebase

scientific article published on 15 December 2015
Drugging cancer genomes

scientific article published in December 2013
Combining multiple structure and sequence alignments to improve sequence detection and alignment: application to the SH2 domains of Janus kinases

scientific article
Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology

scientific article published on 28 June 2013
The complement of enzymatic sets in different species

scientific article
Sequence, structure and energetic determinants of phosphopeptide selectivity of SH2 domains

scientific article published in December 2003
Distinctive Behaviors of Druggable Proteins in Cellular Networks

scientific article (publication date: December 2015)
Collation and data-mining of literature bioactivity data for drug discovery

scientific article
SCOPEC: a database of protein catalytic domains

scientific article
Personalized medicine: patient-predictive panel power

scientific article
A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma

scientific article published on 10 April 2013
Blocking the survival of the nastiest by HSP90 inhibition

scientific article
The kinase polypharmacology landscape of clinical PARP inhibitors

scientific article published on 17 February 2020
Unpicking the combination lock for mutant BRAF and RAS melanomas

scientific article
The Molecular Basis of Predicting Druggability

Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers

scientific article published on 01 July 2019
JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

scientific article published on 01 February 2021
Public resources for chemical probes: the journey so far and the road ahead

scientific article published on 28 November 2019
Evolution of kinase polypharmacology across HSP90 drug discovery

Native size exclusion chromatography-based mass spectrometry (SEC-MS) identifies novel components of the Heat Shock Protein 90-dependent proteome

The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use

Transforming cancer drug discovery with Big Data and AI

scientific article published on 08 July 2019
New open drug activity data at EBI

The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research

R-loop editing by DNA cytosine deaminase APOBEC3B determines the activity of estrogen receptor enhancers

canSAR: update to the cancer translational research and drug discovery knowledgebase

scientific article published on 29 November 2022
Protein Structure Prediction

Evolution of kinase polypharmacology across HSP90 drug discovery

canSAR 2024—an update to the public drug discovery knowledgebase

Native Size-Exclusion Chromatography–Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes

scientific article published in February 2023

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