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List of works by Costas A Lyssiotis

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

scientific article published on 27 March 2013
A colorectal cancer classification system that associates cellular phenotype and responses to therapy

scientific article published on 14 April 2013
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

scientific article
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.

scientific article published on 10 August 2016
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

scientific article published on 22 August 2012
Metabolic Interactions in the Tumor Microenvironment

scientific article
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor.

scientific article published on 30 October 2017
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

scientific article published on January 2016
Dysregulated metabolism contributes to oncogenesis

scientific article
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

scientific article published in February 2016
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

scientific article published in July 2017
Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

scientific article published on 06 September 2013
Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer

scientific article published on January 2017
Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

scientific article published on 18 April 2016
Chemical control of stem cell fate and developmental potential

scientific article published on January 2011
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

scientific article published on October 12, 2015
A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

scientific article published on 23 September 2009
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

scientific article published on 04 March 2019
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.

scientific article
Acetate fuels the cancer engine

scientific article
Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.

scientific article
Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

scientific article published on 10 June 2013
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

scientific article published on 28 February 2019
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

scientific article published on 08 July 2016
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

scientific article published on 01 February 2019
Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells

scientific article
Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation

scientific article published on 02 May 2013
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

scientific article published in September 2017
Metabolic syndrome: F stands for fructose and fat.

scientific article
Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis

scientific article published on 06 December 2016
Emerging roles for SIRT5 in metabolism and cancer

scientific article
Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.

scientific article published on 27 February 2017
Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis.

scientific article published on 3 October 2015
SIRT6 puts cancer metabolism in the driver's seat.

scientific article
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

scientific article published in Nature Communications
Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

scientific article published on 01 April 2019
Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer

scientific article published on 7 June 2016
Emerging concepts: linking hypoxic signaling and cancer metabolism.

scientific article published on 3 May 2012
Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS

scientific article published on 01 February 2019
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

scientific article published on 30 October 2017
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

scientific article published on 01 June 2019
Metabolism and Epigenetics of Pancreatic Cancer Stem Cells

scientific article published on 28 September 2018
A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling.

scientific article
Metabolic Regulation of Redox Balance in Cancer

scientific article published on 08 July 2019
Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation

scientific article
Cysteine depletion induces pancreatic tumor ferroptosis in mice

scientific article published on 01 April 2020
Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma

scientific article published on 27 April 2018
Menin regulates the serine biosynthetic pathway in Ewing sarcoma.

scientific article published on 19 April 2018
Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells

scientific article published on 18 June 2019

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