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List of works by Tom Kirkwood

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Developmental plasticity and human health

scientific article published in July 2004
Deciphering death: a commentary on Gompertz (1825) ‘On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies’

scientific article published on April 19, 2015
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

scientific article published in May 2007
Mitochondrial DNA mutations in human colonic crypt stem cells

scientific article published on November 2003
Human longevity at the cost of reproductive success

scientific article published in Nature
Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study

scientific article
A systematic look at an old problem

scientific article published in Nature
Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study.

scientific article
Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees.

scientific article
Evolution of ageing

scientific article
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article
Age-related frailty and its association with biological markers of ageing

scientific article published on 13 July 2015
What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

scientific article
Food restriction, evolution and ageing

scientific article
Systems biology of ageing and longevity

scientific article published on January 2011
Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study

scientific article published on 16 August 2011
On the Programmed/Non-Programmed Nature of Ageing within the Life History

scientific article published on September 27, 2011
New model of health promotion and disease prevention for the 21st century

scientific article published on 8 July 2008
Testing evolutionary theories of menopause

scientific article published in 2007
Modelling telomere shortening and the role of oxidative stress

scientific article published in February 2002
The free-radical theory of ageing--older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support

scientific article published on 29 May 2012
Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

scientific article
Life-history evolution and the polyphenic regulation of somatic maintenance and survival

scientific article
Grip strength and mortality: a biomarker of ageing?

scientific article published on May 13, 2015
Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

scientific article
Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations

scientific article
Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study

scientific article
Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans

scientific article published in June 2006
Tools for the SBML Community

scientific article published on 12 January 2006
Modelling the actions of chaperones and their role in ageing

scientific article published in January 2005
Telomere-driven replicative senescence is a stress response

scientific article published on 01 March 2003
The connections between general and reproductive senescence and the evolutionary basis of menopause

scientific article published on August 1, 2010
Intrinsic ageing of gut epithelial stem cells

scientific article
Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

scientific article
Towards an e-biology of ageing: integrating theory and data

scientific article published in March 2003
The old worm turns more slowly

scientific article published in Nature
Improving retention of very old participants in longitudinal research: experiences from the Newcastle 85+ study

scientific article
A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation

scientific article published on October 10, 2012
A modified and automated version of the 'Fluorimetric Detection of Alkaline DNA Unwinding' method to quantify formation and repair of DNA strand breaks

scientific article published on 23 April 2009
Mitochondria and ageing: winning and losing in the numbers game.

scientific article published in September 2007
Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short‐lived animals

scientific article published on June 7, 2013
Modelling cellular senescence as a result of telomere state

scientific article published in June 2003
Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.

scientific article
Can aging be programmed? A critical literature review

scientific article published on 17 August 2016
The predictive adaptive response: modeling the life-history evolution of the butterfly Bicyclus anynana in seasonal environments

scientific article
A comparison of subjective and objective measures of physical activity from the Newcastle 85+ study.

scientific article published on 27 May 2015
Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study

scientific article published on 11 October 2013
Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo

scientific article
Modelling the disposable soma theory of ageing

scientific article published in January 2005
Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging

scientific article published on 03 February 2014

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