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List of works by Alan V. Boddy

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Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

scientific article published on December 2008
A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours.

scientific article
Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.

scientific article
Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma

scientific article published in August 2002
Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer

scientific article published on 22 March 2016
Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

scientific article
A phase I and pharmacokinetic study of paclitaxel poliglumex (XYOTAX), investigating both 3-weekly and 2-weekly schedules

scientific article published in November 2005
Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

scientific article
Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development

scientific article
Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

scientific article
Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee

scientific article published on 01 January 1998
Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.

scientific article
Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions.

scientific article published on 4 August 2017
Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System.

scientific article published on 5 October 2015
Stereoselectivity in pharmacokinetics: a general theory

scientific article published on May 1, 1991
Imagestream detection and characterisation of circulating tumour cells - A liquid biopsy for hepatocellular carcinoma?

scientific article published on 27 April 2016
The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide

scientific article published on 01 September 1993
The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion

scientific article published on 01 January 1995
Pharmacokinetics and metabolism of 13-cis-retinoic acid (isotretinoin) in children with high-risk neuroblastoma - a study of the United Kingdom Children's Cancer Study Group.

scientific article published on 16 January 2007
A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.

scientific article
Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo

scientific article published on 11 October 2012
Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

scientific article
Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.

scientific article published on 26 April 2010
Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma.

scientific article
Cyclophosphamide metabolism in children with non-Hodgkin's lymphoma

scientific article published in January 2004
A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin

scientific article
Comparison of methods for the estimation of carboplatin pharmacokinetics in paediatric cancer patients

scientific article published in October 1995
Population pharmacokinetics of doxorubicin: establishment of a NONMEM model for adults and children older than 3 years

scientific article published on 13 January 2013
Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules

scientific article published on 20 February 2014
A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study

scientific article
Population pharmacokinetics of carboplatin in children

scientific article published on 01 April 1996
Saturable metabolism of continuous high-dose ifosfamide with mesna and GM-CSF: a pharmacokinetic study in advanced sarcoma patients. Swiss Group for Clinical Cancer Research (SAKK).

scientific article
Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells

scientific article published on February 2005
Pharmacokinetic investigation of imatinib using accelerator mass spectrometry in patients with chronic myeloid leukemia

scientific article published in July 2007
Comparative anticonvulsant potency and pharmacokinetics of (+)-and (-)-enantiomers of stiripentol

scientific article published on June 1, 1992
Thiothymidine combined with UVA as a potential novel therapy for bladder cancer.

scientific article
Influence of antibiotics on the recovery and kinetics of Saccharomyces boulardii in rats

scientific article published in June 1991
Population pharmacokinetics of adjuvant cyclophosphamide, methotrexate and 5-fluorouracil (CMF).

scientific article
Characterisation of the clinical pharmacokinetics of actinomycin D and the influence of ABCB1 pharmacogenetic variation on actinomycin D disposition in children with cancer

scientific article
High-resolution imaging for the detection and characterisation of circulating tumour cells from patients with oesophageal, hepatocellular, thyroid and ovarian cancers

scientific article published on 14 July 2015
Phase I study of temozolomide plus paclitaxel in patients with advanced malignant melanoma and associated in vitro investigations.

scientific article published on March 2005
Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy

scientific article published on 01 December 2011
Pharmacogenetics of genes across the doxorubicin pathway.

scientific article published on October 2011
Intrasubject variation in children of ifosfamide pharmacokinetics and metabolism during repeated administration

scientific article published on 01 January 1996
Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor

scientific article published on 10 October 2006
Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics

scientific article published on 01 June 1996
Estimation of glomerular filtration rate in paediatric cancer patients using 51CR-EDTA population pharmacokinetics

scientific article published on January 2004
Formulation of Biologically-Inspired Silk-Based Drug Carriers for Pulmonary Delivery Targeted for Lung Cancer

scientific article published on 3 August 2015
NAD(P)H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism

scientific article published on 01 March 2007
Efficiency of drug targeting: steady-state considerations using a three-compartment model

scientific article published on 01 May 1989

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