List of works - José A. Esté

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

scientific article published in January 1998

Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.

scientific article

HIV entry inhibitors.

scientific article

Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication

article

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4

scientific article published on August 1, 1997

Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope

scientific article

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

scientific article

Secretion of interferon-gamma by human macrophages demonstrated at the single-cell level after costimulation with interleukin (IL)-12 plus IL-18

scientific article published on 28 August 2008

Role of the human immunodeficiency virus type 1 envelope gene in viral fitness.

scientific article

A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission

scientific article published on 03 July 2008

RNA interference of HIV replication

scientific article

SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction.

scientific article published on 10 September 2015

Cell-Surface-Expressed HIV-1 Envelope Induces the Death of CD4 T Cells during GP41-Mediated Hemifusion-like Events

scientific article published on 01 January 2003

The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling

article

R5 HIV gp120-mediated cellular contacts induce the death of single CCR5-expressing CD4 T cells by a gp41-dependent mechanism

article

Evaluation of the anti-HIV activity of statins

scientific article published in October 2005

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

scientific article published on 22 June 2011

ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression

scientific article

HIV-1 resistance to the gp41-dependent fusion inhibitor C-34.

scientific article

p21 regulates the HIV-1 restriction factor SAMHD1.

scientific article published on 7 March 2014

Antiretroviral agents effectively block HIV replication after cell-to-cell transfer

scientific article

Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients

scientific article published on 01 May 2005

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

scientific article published on 26 April 2016

Treatment of monocytes with interleukin (IL)-12 plus IL-18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9 and CXCL10.

scientific article

HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection

scientific article published on 5 April 2009

Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026.

scientific article published on 8 January 2008

CXCR4 and SDF-1 expression in B-cell chronic lymphocytic leukemia and stage of the disease

scientific article published on 29 May 2003

Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

article

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

scientific article published in Nature Communications

Cell type-dependent effect of sodium valproate on human immunodeficiency virus type 1 replication in vitro.

scientific article published on January 1997

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages

scientific article

Virus entry as a target for anti-HIV intervention

scientific article (publication date: September 2003)

Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

scientific article published on September 2014

SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors

scientific article

Differential antiviral activity of derivatized dextrans

scientific article

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells

scientific article

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers

scientific article published on 25 July 2014

Immunological and virological study of enfuvirtide-treated HIV-positive patients

scientific article

Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection

scientific article

Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages

scientific article

Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants

scientific article

5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile

scientific article published on 17 July 2008

A bacteriophage lambda-based genetic screen for characterization of the activity and phenotype of the human immunodeficiency virus type 1 protease

scientific article

A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs

scientific article

Compensatory mutations rescue the virus replicative capacity of VIRIP-resistant HIV-1.

scientific article

Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1.

scientific article

Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein

scientific article

Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants.

scientific article

Characterization of the influence of mediator complex in HIV-1 transcription

scientific article

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article

List of works by José A. Esté

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.

HIV entry inhibitors.

Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4

Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

Secretion of interferon-gamma by human macrophages demonstrated at the single-cell level after costimulation with interleukin (IL)-12 plus IL-18

Role of the human immunodeficiency virus type 1 envelope gene in viral fitness.

A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission

RNA interference of HIV replication

SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction.

Cell-Surface-Expressed HIV-1 Envelope Induces the Death of CD4 T Cells during GP41-Mediated Hemifusion-like Events

The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling

R5 HIV gp120-mediated cellular contacts induce the death of single CCR5-expressing CD4 T cells by a gp41-dependent mechanism

Evaluation of the anti-HIV activity of statins

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression

HIV-1 resistance to the gp41-dependent fusion inhibitor C-34.

p21 regulates the HIV-1 restriction factor SAMHD1.

Antiretroviral agents effectively block HIV replication after cell-to-cell transfer

Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

Treatment of monocytes with interleukin (IL)-12 plus IL-18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9 and CXCL10.

HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection

Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026.

CXCR4 and SDF-1 expression in B-cell chronic lymphocytic leukemia and stage of the disease

Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

Cell type-dependent effect of sodium valproate on human immunodeficiency virus type 1 replication in vitro.

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages

Virus entry as a target for anti-HIV intervention

Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors

Differential antiviral activity of derivatized dextrans

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers

Immunological and virological study of enfuvirtide-treated HIV-positive patients

Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection

Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages

Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants

5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile

A bacteriophage lambda-based genetic screen for characterization of the activity and phenotype of the human immunodeficiency virus type 1 protease

A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs

Compensatory mutations rescue the virus replicative capacity of VIRIP-resistant HIV-1.

Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1.

Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein

Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants.

Characterization of the influence of mediator complex in HIV-1 transcription

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors