List of works - Michele Saviano

Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex

scientific article

Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites

scientific article

Selectively functionalized cyclodextrins and their metal complexes

scientific article published on 30 June 2009

Discovering protein secondary structures: Classification and description of isolated α-turns

scientific article (publication date: June 1996)

Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism

scientific article

AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress

scientific article published on 28 May 2010

A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs

scientific journal article

Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit

scientific article (publication date: 2011)

Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation

scientific article

Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites

scientific article published on December 2001

Cationic liposomes as delivery systems for double-stranded PNA-DNA chimeras exhibiting decoy activity against NF-kappaB transcription factors

scientific article

Maroteaux-lamy syndrome: five novel mutations and their structural localization

scientific article published in February 1999

Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5).

scientific article published on 11 August 2009

Structural and kinetic characterization of native laccases from Pleurotus ostreatus, Rigidoporus lignosus, and Trametes trogii

scientific article published in April 2001

A Modified Cyclodextrin with a Fully Encapsulated Dansyl Group: Self-Inclusion in the Solid State and in Solution

Peptide α/310-Helix Dimorphism in the Crystal State

scientific article published in 2007

The psychrophilic bacterium Pseudoalteromonas halosplanktis TAC125 possesses a gene coding for a cold-adapted feruloyl esterase activity that shares homology with esterase enzymes from γ-proteobacteria and yeast

article

Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction

scientific article

Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells

scientific article

Nitroxyl peptides as catalysts of enantioselective oxidations

scientific article published in January 2002

Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3.

scientific article

Crystal structure of an S-formylglutathione hydrolase from Pseudoalteromonas haloplanktis TAC125

scientific article

Novel and Selective αvβ3Receptor Peptide Antagonist: Design, Synthesis, and Biological Behavior

scientific article published on 01 June 2006

Peptides for tumour therapy and diagnosis: current status and future directions.

scientific article published on January 2009

γ Sulphate PNA (PNA S): highly selective DNA binding molecule showing promising antigene activity

scientific article

In silico investigation and targeting of amyloid β oligomers of different size

scientific article published on 24 May 2013

Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites

scientific article published on 6 November 2008

Beta-alanine containing peptides: a novel molecular tool for the design of gamma-turns

scientific article published on 01 February 1992

Crystal structure of the W35A mutant thioredoxinh fromChlamydomonas reinhardtii: The substitution of the conserved active site Trp leads to modifications in the environment of the two catalytic cysteines

scientific article published on 01 January 2000

Does tetracycline bind helix 2 of prion? An integrated spectroscopical and computational study of the interaction between the antibiotic and α helix 2 human prion protein fragments

scholarly article by Luisa Ronga published in December 2006

IgE-binding properties and selectivity of peptide mimics of the FcvarepsilonRI binding site

scientific article

Molecular dynamics simulations of PNA–PNA and PNA–DNA duplexes by the use of new parameters implemented in the GROMACS package: a conformational and dynamics study

scientific article published on February 7, 2014

Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery

Solvent-mediated conformational transition in β-alanine containing cyclic peptides. VIII

scientific article published on 01 June 1996

Benzophenone photophore flexibility and proximity: molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue

scientific article

Defect peptide chemistry: perturbations in the structure of a homopentapeptide induced by a guest residue interrupting side-chain regularity.

scientific article

?-Alanine containing cyclic peptides with predetermined turned structure. V

scientific article published on 01 November 1994

N-heterocyclic carbene catalysed homoenolate addition to 3-methyl-4-nitro-5-styrylisoxazoles

article

New peptide nucleic acid analogues: synthesis and applications

scientific article published on August 2007

RGDechi-hCit: αvβ3 selective pro-apoptotic peptide as potential carrier for drug delivery into melanoma metastatic cells

scientific article

X-ray Diffraction Analysis and Conformational Energy Computations of β-Turn and 310-Helical Peptides Based on α-Amino Acids with an Olefinic Side Chain. Implications for Ring-Closing Metathesis

article

Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting.

scientific article

Conformational restriction through C alpha i C alpha i cyclization: Ac12c, the largest cycloaliphatic C alpha,alpha- disubstituted glycine known

scientific article

Insights into the mechanism of interaction between trehalose-conjugated beta-sheet breaker peptides and Aβ(1–42) fibrils by molecular dynamics simulations

scientific article published on November 1, 2013

?-Alanine containing cyclic peptides with turned structure: The?pseudo type II ?-turn.? VI

scientific article published on 01 November 1994

gamma-Hydroxymethyl PNAs: Synthesis, interaction with DNA and inhibition of protein/DNA interactions

scientific article

Fluorescence study for selecting specific ligands toward HER2 receptor: an example of receptor fragment approach

scientific article

Conformational studies of chiral d-Lys-PNA and achiral PNA system in binding with DNA or RNA through a molecular dynamics approach

scientific article published on 06 August 2014

Specific interaction between cyclophilin and cyclic peptides

scientific article published on September 1, 1995

A Combined NMR and Computational Approach to Determine the RGDechi-hCit-αv β3 Integrin Recognition Mode in Isolated Cell Membranes

scientific article published on 09 November 2015

List of works by Michele Saviano

Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex

Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites

Selectively functionalized cyclodextrins and their metal complexes

Discovering protein secondary structures: Classification and description of isolated α-turns

Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism

AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress

A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs

Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit

Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation

Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites

Cationic liposomes as delivery systems for double-stranded PNA-DNA chimeras exhibiting decoy activity against NF-kappaB transcription factors

Maroteaux-lamy syndrome: five novel mutations and their structural localization

Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5).

Structural and kinetic characterization of native laccases from Pleurotus ostreatus, Rigidoporus lignosus, and Trametes trogii

A Modified Cyclodextrin with a Fully Encapsulated Dansyl Group: Self-Inclusion in the Solid State and in Solution

Peptide α/310-Helix Dimorphism in the Crystal State

The psychrophilic bacterium Pseudoalteromonas halosplanktis TAC125 possesses a gene coding for a cold-adapted feruloyl esterase activity that shares homology with esterase enzymes from γ-proteobacteria and yeast

Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction

Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells

Nitroxyl peptides as catalysts of enantioselective oxidations

Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3.

Crystal structure of an S-formylglutathione hydrolase from Pseudoalteromonas haloplanktis TAC125

Novel and Selective αvβ3Receptor Peptide Antagonist: Design, Synthesis, and Biological Behavior

Peptides for tumour therapy and diagnosis: current status and future directions.

γ Sulphate PNA (PNA S): highly selective DNA binding molecule showing promising antigene activity

In silico investigation and targeting of amyloid β oligomers of different size

Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites

Beta-alanine containing peptides: a novel molecular tool for the design of gamma-turns

Crystal structure of the W35A mutant thioredoxinh fromChlamydomonas reinhardtii: The substitution of the conserved active site Trp leads to modifications in the environment of the two catalytic cysteines

Does tetracycline bind helix 2 of prion? An integrated spectroscopical and computational study of the interaction between the antibiotic and α helix 2 human prion protein fragments

IgE-binding properties and selectivity of peptide mimics of the FcvarepsilonRI binding site

Molecular dynamics simulations of PNA–PNA and PNA–DNA duplexes by the use of new parameters implemented in the GROMACS package: a conformational and dynamics study

Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery

Solvent-mediated conformational transition in β-alanine containing cyclic peptides. VIII

Benzophenone photophore flexibility and proximity: molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue

Defect peptide chemistry: perturbations in the structure of a homopentapeptide induced by a guest residue interrupting side-chain regularity.

?-Alanine containing cyclic peptides with predetermined turned structure. V

N-heterocyclic carbene catalysed homoenolate addition to 3-methyl-4-nitro-5-styrylisoxazoles

New peptide nucleic acid analogues: synthesis and applications

RGDechi-hCit: αvβ3 selective pro-apoptotic peptide as potential carrier for drug delivery into melanoma metastatic cells

X-ray Diffraction Analysis and Conformational Energy Computations of β-Turn and 310-Helical Peptides Based on α-Amino Acids with an Olefinic Side Chain. Implications for Ring-Closing Metathesis

Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting.

Conformational restriction through C alpha i C alpha i cyclization: Ac12c, the largest cycloaliphatic C alpha,alpha- disubstituted glycine known

Insights into the mechanism of interaction between trehalose-conjugated beta-sheet breaker peptides and Aβ(1–42) fibrils by molecular dynamics simulations

?-Alanine containing cyclic peptides with turned structure: The?pseudo type II ?-turn.? VI

gamma-Hydroxymethyl PNAs: Synthesis, interaction with DNA and inhibition of protein/DNA interactions

Fluorescence study for selecting specific ligands toward HER2 receptor: an example of receptor fragment approach

Conformational studies of chiral d-Lys-PNA and achiral PNA system in binding with DNA or RNA through a molecular dynamics approach

Specific interaction between cyclophilin and cyclic peptides

A Combined NMR and Computational Approach to Determine the RGDechi-hCit-αv β3 Integrin Recognition Mode in Isolated Cell Membranes